Jove
Visualize
Contact Us

Related Experiment Video

Updated: Jun 23, 2026

Optimization of Radiochemical Reactions using Droplet Arrays
10:54

Optimization of Radiochemical Reactions using Droplet Arrays

Published on: February 12, 2021

Microreactors for radiopharmaceutical synthesis.

Arkadij M Elizarov1

  • 1Siemens MI Biomarker Research, 6100 Bristol Parkway, Culver City, CA90230, USA. arkadij.elizarov@siemens.com

Lab on a Chip
|May 7, 2009
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Flow optimization study of a batch microfluidics PET tracer synthesizing device.

Biomedical microdevices·2010
Same author

Pre-clinical evaluation of a 3-nitro-1,2,4-triazole analogue of [18F]FMISO as hypoxia-selective tracer for PET.

Nuclear medicine and biology·2010
Same author

Design and optimization of coin-shaped microreactor chips for PET radiopharmaceutical synthesis.

Journal of nuclear medicine : official publication, Society of Nuclear Medicine·2010
Same author

Complete charge pooling is prevented in viologen-based dendrimers by self-protection.

Chemistry (Weinheim an der Bergstrasse, Germany)·2004
Same author

Polyvalent interactions in unnatural recognition processes.

The Journal of organic chemistry·2004
Same author

Polyvalent scaffolds. Counting the number of seats available for eosin guest molecules in viologen-based host dendrimers.

Journal of the American Chemical Society·2004
Same journal

Microfluidic rare cell analysis beyond counting: workflow design from enrichment to multi-omics.

Lab on a chip·2026
Same journal

A sperm racetrack to separate sperm by swim speed.

Lab on a chip·2026
Same journal

Controlled encapsulation and droplet size prediction in two-step microfluidic double emulsions.

Lab on a chip·2026
Same journal

A particulate blood-mimicking fluid with physiological biconcave geometry for microscale hemorheology.

Lab on a chip·2026
Same journal

Multicellular sensor arrays fabricated by capillary stamping for pattern-based odor discrimination.

Lab on a chip·2026
Same journal

A real-time microfluidic surveillance system for multiplex detection of heavy metal contamination in wastewater.

Lab on a chip·2026
See all related articles
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Microfluidics offers advantages for radiopharmaceutical synthesis, especially for short-lived isotopes like fluorine-18 and carbon-11 used in Positron Emission Tomography (PET). Further development is needed for widespread commercial adoption.

Area of Science:

  • Radiopharmaceutical Chemistry
  • Microfluidic Engineering
  • Nuclear Medicine

Background:

  • Microfluidics shows promise for organic synthesis but has limited application in radiopharmaceutical synthesis.
  • Radiopharmaceutical synthesis requires rapid, high-yielding reactions for short-lived isotopes (e.g., 18F, 11C).
  • Remote control of devices is crucial for handling radioactive materials.

Purpose of the Study:

  • To review current microfluidic technologies for radiopharmaceutical synthesis.
  • To analyze unmet needs hindering commercial application of microfluidics in this field.
  • To assess the potential of microfluidics for Positron Emission Tomography (PET) biomarker preparation.

Main Methods:

  • Review of reported microfluidic devices and techniques for radiosynthesis.

More Related Videos

Automated Radiochemical Synthesis of [18F]3F4AP: A Novel PET Tracer for Imaging Demyelinating Diseases
11:03

Automated Radiochemical Synthesis of [18F]3F4AP: A Novel PET Tracer for Imaging Demyelinating Diseases

Published on: May 29, 2017

An Inexpensive Adaptation of a Commercial Microwave Reactor for Solid Phase Peptide Synthesis
06:19

An Inexpensive Adaptation of a Commercial Microwave Reactor for Solid Phase Peptide Synthesis

Published on: November 22, 2024

Related Experiment Videos

Last Updated: Jun 23, 2026

Optimization of Radiochemical Reactions using Droplet Arrays
10:54

Optimization of Radiochemical Reactions using Droplet Arrays

Published on: February 12, 2021

Automated Radiochemical Synthesis of [18F]3F4AP: A Novel PET Tracer for Imaging Demyelinating Diseases
11:03

Automated Radiochemical Synthesis of [18F]3F4AP: A Novel PET Tracer for Imaging Demyelinating Diseases

Published on: May 29, 2017

An Inexpensive Adaptation of a Commercial Microwave Reactor for Solid Phase Peptide Synthesis
06:19

An Inexpensive Adaptation of a Commercial Microwave Reactor for Solid Phase Peptide Synthesis

Published on: November 22, 2024

  • Analysis of challenges and limitations in current microfluidic radiopharmaceutical synthesis.
  • Identification of key areas for future development and commercialization.

    • Main Results:

    • Several microfluidic approaches have been demonstrated to replace conventional radiosynthesis steps.
    • Promising results have been achieved, generating scientific interest.
    • No microfluidic technology has yet achieved broad commercial application in radiopharmaceutical production.

    Conclusions:

    • Microfluidics holds significant potential for improving radiopharmaceutical synthesis, particularly for PET imaging agents.
    • Addressing unmet needs is critical for the successful commercialization and widespread adoption of microfluidic technology.
    • Further research and development are required to overcome current barriers to implementation.