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A Method for Labeling Vasculature in Embryonic Mice
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[Expression and significance of basic fibroblast growth factor in infant vascular anomalies]

Li Luo1, Hui Huang, Da-Hai Yu

  • 1College of Stomatology, Guangxi Medical University, Nanning 530021, China. luoli315@hotmail.com

Shanghai Kou Qiang Yi Xue = Shanghai Journal of Stomatology
|May 7, 2009
PubMed

Insights

Basic fibroblast growth factor (bFGF) levels in infant tumor blood from venous malformations are elevated compared to peripheral blood. However, peripheral blood bFGF cannot distinguish hemangioma from vascular malformations.

Area of Science:

  • Biochemistry
  • Pediatric Medicine
  • Oncology

Background:

  • Vascular anomalies in infants, including hemangiomas and vascular malformations, present diagnostic challenges.
  • Basic fibroblast growth factor (bFGF) is implicated in angiogenesis and tissue development.
  • Understanding bFGF expression may offer insights into differentiating these pediatric conditions.

Purpose of the Study:

  • To measure basic fibroblast growth factor (bFGF) levels in infant peripheral blood and tumor blood of vascular malformations and hemangiomas.
  • To assess the potential of peripheral blood bFGF levels to differentiate hemangioma from vascular malformations in infants.

Main Methods:

  • Enzyme-linked immunosorbent assay (ELISA) was used to quantify bFGF levels.
  • Study included infants with vascular malformations (49), hemangioma (32), and normal controls (23).
  • Tumor blood from 14 infants with venous malformations was also analyzed.
  • Statistical analysis using SPSS 11.5, including t-tests and ANOVA, was performed.

Main Results:

  • bFGF levels were significantly higher in the tumor blood of infants with venous malformations compared to their peripheral blood (P<0.05).
  • No significant differences in peripheral blood bFGF levels were observed among infants with hemangioma, vascular malformations, and normal controls (P>0.05).

Conclusions:

  • Elevated bFGF expression in tumor blood is characteristic of infantile venous malformations.
  • Peripheral blood bFGF levels are insufficient for differentiating hemangioma from vascular malformations in infants.
Abstract

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