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Related Concept Videos

Pharmacodynamics in Geriatric Patients: Effects of Age01:27

Pharmacodynamics in Geriatric Patients: Effects of Age

Age-related pharmacokinetic changes are extensively documented, but understanding age-related pharmacodynamic alterations is relatively limited. This knowledge gap can be partly attributed to the complexity of developing appropriate measures of drug responses compared to bioanalytical methods for determining drug concentrations.Most information regarding age-related differences in human pharmacodynamics originates from cross-sectional studies. However, these studies assume that observed mean...
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Absorption01:22

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Absorption

As individuals age, their body's physiology evolves, affecting drug pharmacokinetics. The most apparent changes occur in the gastrointestinal tract, where an increase in gastric pH, a delay in gastric emptying, and a reduction in gastrointestinal motility are observed. Remarkably, these changes do not substantially modify the absorption of orally administered drugs, particularly those absorbed via passive diffusion.Transdermal drug delivery emerges as a highly viable method for older adults due...
Drug Dosing: Geriatric Patients01:15

Drug Dosing: Geriatric Patients

Elderly individuals encompass a diverse population with varying degrees of age-related physiological changes. Defining the elderly presents challenges, as the geriatric population is often arbitrarily categorized as individuals older than 65. However, many individuals in this group lead active and healthy lives, with an increasing number surpassing 85 years and falling into the older elderly category. Physiological changes associated with aging impact performance capacity and homeostatic...
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Distribution01:00

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Distribution

Drug distribution in the human body is influenced by several factors, including plasma protein concentration, body composition, blood flow, tissue-protein concentration, and tissue fluid pH. Among these, changes in plasma protein concentration and body composition due to aging significantly affect how drugs are distributed within the body. Specifically, aging is associated with a decrease in albumin levels by about 10% and an increase in α1-acid glycoprotein levels. These alterations are not...
Effect of Hepatic Disease on Pharmacokinetics: Dose Adjustments Due to Hepatic Impairment01:08

Effect of Hepatic Disease on Pharmacokinetics: Dose Adjustments Due to Hepatic Impairment

Hepatic impairment, characterized by decreased liver function, does not uniformly mandate adjustments in drug dosage. Whether dosage modifications are necessary depends on various factors related to the drug's metabolism and elimination pathways. If a drug is primarily excreted via the kidneys and bypasses significant hepatic processing, if it undergoes minimal metabolic transformation in the liver, or if it is volatile and primarily expelled through the lungs, dose adjustments may not be...
Factors Affecting Drug Response: Overview01:21

Factors Affecting Drug Response: Overview

When it comes to infants and young children, they are typically administered smaller doses of medication in comparison to adults. This is primarily because their organ functions still need to fully develop, meaning their bodies are not as efficient at metabolizing or eliminating drugs. Additionally, their blood-brain barrier is more permeable than in adults. As a result, high concentrations of drugs can easily penetrate the central nervous system (CNS), potentially leading to neurological...

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Related Experiment Video

Updated: Jun 23, 2026

Brain Morphology of Cannabis Users With or Without Psychosis: A Pilot MRI Study
07:30

Brain Morphology of Cannabis Users With or Without Psychosis: A Pilot MRI Study

Published on: August 18, 2020

Gender differences among older heroin users.

Alison B Hamilton1, Christine E Grella

  • 1UCLA Integrated Substance Abuse Programs, Department of Psychiatry and Biobehavioral Sciences, University of Los Angeles, Los Angeles, CA, USA. alisonh@ucla.edu

Journal of Women & Aging
|May 7, 2009
PubMed
Summary
This summary is machine-generated.

Older adults with heroin addiction history showed few gender differences in social or health issues. Shared experiences of aging and drug use were more prominent than gender-specific challenges.

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Brain Morphology of Cannabis Users With or Without Psychosis: A Pilot MRI Study
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Published on: March 23, 2022

Area of Science:

  • Gerontology
  • Addiction Medicine
  • Sociology

Background:

  • Long-term heroin dependence impacts aging individuals.
  • Understanding gender differences in this population is crucial.

Purpose of the Study:

  • To investigate gender differences in social, family, and health aspects among older adults with a history of heroin addiction.

Main Methods:

  • Eight gender-specific focus groups (19 women, 19 men, aged 50+) with long-term heroin dependence histories.
  • Participants recruited from a methadone maintenance clinic and the Los Angeles community.

Main Results:

  • Minor gender differences observed primarily in group dynamics.
  • Women focused on family impacts; men expressed surprise at survival.
  • Hepatitis C and mental health issues were common concerns.

Conclusions:

  • Overriding similarities in the interplay of drug use and aging were found, rather than significant gender disparities.
  • Further longitudinal research is needed to clarify the complex relationships between aging, addiction, gender, and health outcomes.