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Updated: Jun 23, 2026

Generation of Human Alloantigen-specific T Cells from Peripheral Blood
09:47

Generation of Human Alloantigen-specific T Cells from Peripheral Blood

Published on: November 21, 2014

Allogeneic memory T cell response

Benny J Chen1

  • 1Division of Cellular Therapy/BMT, Duke University Medical Center, Durham, North Carolina, USA.

Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation
|May 7, 2009
PubMed

Recent data have revealed marked differences in alloresponses mediated by memory T cells during GVH and host-versus-graft (HVG) reactions (summarized in Table 1). Even though the mechanisms are not completely understood, it is clear that all memory T cells including nonallospecific, crossreactive, and allospecific memory T cells have decreased ability to induce GVHD. Selection of memory T cells or removal of naïve T cells will not only prevent GVHD, but could also enhance immune reconstitution, facilitate engraftment, and have the potential to enhance antitumor effects. A clinical trial has been planned. Successful translation of this approach in the clinic will improve the safety, enhance the effectiveness, and broaden the scope of allogeneic hematopoietic stem cell transplantation.

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