Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Cells of the Adaptive Immune Response01:23

Cells of the Adaptive Immune Response

The T and B lymphocytes of the adaptive immune system develop from common lymphoid progenitor cells in the bone marrow. These progenitors give rise to precursors that eventually develop into both T and B lymphocytes. As these precursors mature, they gain the ability to detect and respond to foreign antigens in the body, a process known as immunocompetence. Additionally, these precursors acquire self-tolerance, a process that ensures they do not react to self-antigens. This intricate system...
Cell-mediated Immune Responses01:40

Cell-mediated Immune Responses

Overview
T Cell Activation and Clonal Selection01:22

T Cell Activation and Clonal Selection

T cells are integral to our adaptive immune system, recognizing and effectively responding to foreign antigens. T cell activation and clonal selection are pivotal in orchestrating this immune response. This article elucidates these mechanisms, detailing the roles of cluster of differentiation (CD) markers, major histocompatibility complex (MHC) molecules, costimulatory signals, and the process of clonal selection.
Naive T cells that have not yet encountered an antigen express two primary CD...
Immunological Memory01:23

Immunological Memory

Immunological memory, a pivotal pillar of the adaptive immune system, is responsible for the body's ability to remember and respond more swiftly and effectively to previously encountered pathogens. This remarkable feature is what makes vaccines so effective in preventing diseases.
What is Immunological Memory?
Immunological memory is an integral function of the immune system that allows it to recognize and react more rapidly and effectively to pathogens previously encountered. This feature is...
Special Features of Adaptive Immunity01:20

Special Features of Adaptive Immunity

The adaptive immune system, a crucial component of the overall immune response, offers a highly specialized defense against pathogens. It involves specific cell types and features, enabling it to combat infections effectively and efficiently.
The primary cell types involved in adaptive immunity are T cells and B cells. Each type has a unique role in defending the body against pathogens. T cells are responsible for cell-mediated immunity. They identify and eliminate infected cells directly,...
B Cell Activation and Differentiation01:24

B Cell Activation and Differentiation

The adaptive immune response, a sophisticated defense mechanism, relies on the activation and differentiation of B lymphocytes, or B cells. These processes enable our bodies to mount a tailored response against specific pathogens such as bacteria, free virus particles, toxins, and parasites.
When naive B cells encounter a specific antigen that can bind to the B cell receptor (BCR) on their surface, they undergo sensitization to respond to the antigen's presence. Sensitization begins with...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Exogenous Growth Hormone Exacerbates Post-Irradiation Atherosclerosis in Susceptible Epicardial Coronary Arteries.

Toxicologic pathology·2024
Same author

Endothelial Cell Derived Extracellular Vesicles and Hematopoiesis.

Radiation research·2024
Same author

Prebiotic galactooligosaccharides interact with mouse gut microbiota to attenuate acute graft-versus-host disease.

Blood·2022
Same author

Alphavirus Replicon Particle Vaccine Breaks B Cell Tolerance and Rapidly Induces IgG to Murine Hematolymphoid Tumor Associated Antigens.

Frontiers in immunology·2022
Same author

T cell metabolism in graft-versus-host disease.

Blood science (Baltimore, Md.)·2022
Same author

Targeting Glycolysis in Alloreactive T Cells to Prevent Acute Graft-<i>Versus</i>-Host Disease While Preserving Graft-Versus-Leukemia Effect.

Frontiers in immunology·2022
Same journal

ASTCT Notes.

Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation·2021
Same journal

ASTCT Notes.

Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation·2021
Same journal

End of headings.

Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation·2021
Same journal

ASTCT Notes.

Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation·2021
Same journal

Improving Hematopoietic Stem Cell Transplant in the Elderly: Can We Finally Start to Impact Nonrelapse Mortality?

Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation·2020
Same journal

Cardiovascular Events Associated with Chimeric Antigen Receptor T Cell Therapy: Cross-Sectional FDA Adverse Events Reporting System Analysis.

Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation·2020
See all related articles

Related Experiment Video

Updated: Jun 23, 2026

Generation of Human Alloantigen-specific T Cells from Peripheral Blood
09:47

Generation of Human Alloantigen-specific T Cells from Peripheral Blood

Published on: November 21, 2014

Allogeneic memory T cell response.

Benny J Chen1

  • 1Division of Cellular Therapy/BMT, Duke University Medical Center, Durham, North Carolina, USA.

Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation
|May 7, 2009
PubMed
Summary
This summary is machine-generated.

Selecting specific memory T cells or removing naive T cells can prevent graft-versus-host disease (GVHD). This approach may also improve immune reconstitution and enhance anti-tumor effects in stem cell transplantation.

More Related Videos

Generation of Multivirus-specific T Cells to Prevent/treat Viral Infections after Allogeneic Hematopoietic Stem Cell Transplant
08:52

Generation of Multivirus-specific T Cells to Prevent/treat Viral Infections after Allogeneic Hematopoietic Stem Cell Transplant

Published on: May 27, 2011

Measurement of T Cell Alloreactivity Using Imaging Flow Cytometry
09:04

Measurement of T Cell Alloreactivity Using Imaging Flow Cytometry

Published on: April 19, 2017

Related Experiment Videos

Last Updated: Jun 23, 2026

Generation of Human Alloantigen-specific T Cells from Peripheral Blood
09:47

Generation of Human Alloantigen-specific T Cells from Peripheral Blood

Published on: November 21, 2014

Generation of Multivirus-specific T Cells to Prevent/treat Viral Infections after Allogeneic Hematopoietic Stem Cell Transplant
08:52

Generation of Multivirus-specific T Cells to Prevent/treat Viral Infections after Allogeneic Hematopoietic Stem Cell Transplant

Published on: May 27, 2011

Measurement of T Cell Alloreactivity Using Imaging Flow Cytometry
09:04

Measurement of T Cell Alloreactivity Using Imaging Flow Cytometry

Published on: April 19, 2017

Area of Science:

  • Immunology
  • Transplantation immunology

Background:

  • Alloresponses mediated by memory T cells differ significantly between graft-versus-host (GVH) and host-versus-graft (HVG) reactions.
  • Memory T cells, including nonallospecific, crossreactive, and allospecific types, demonstrate a reduced capacity to induce GVHD.

Purpose of the Study:

  • To investigate the potential of selecting memory T cells or removing naive T cells to prevent GVHD.
  • To explore the broader benefits of this approach, such as enhanced immune reconstitution, improved engraftment, and augmented anti-tumor effects.

Main Methods:

  • Analysis of recent data comparing alloresponses in GVH and HVG reactions.
  • Evaluation of the functional capacity of different memory T cell subsets in inducing GVHD.

Main Results:

  • Memory T cells exhibit a decreased ability to induce GVHD.
  • Selection or removal strategies targeting T cell populations show promise in preventing GVHD.

Conclusions:

  • Targeting specific T cell populations (memory or naive) offers a novel strategy to prevent GVHD.
  • This approach holds potential to improve safety, efficacy, and applicability of allogeneic hematopoietic stem cell transplantation, with planned clinical trials.