Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Changes in vascular morphology in essential hypertension.

A M Heagerty1

  • 1Department of Medicine, University Hospital of South Manchester, West Didsbury, UK.

Journal of Human Hypertension
|August 1, 1991
PubMed
Summary

High blood pressure (hypertension) increases cardiovascular risk. New treatments should target not only blood pressure but also reverse harmful vascular structural changes to reduce cardiac events.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Perivascular adipose tissue: An immune cell metropolis.

Experimental physiology·2020
Same author

Diabetes, Obesity and Atrial Fibrillation: Epidemiology, Mechanisms and Interventions.

Journal of atrial fibrillation·2017
Same author

Stimulated release of a hyperpolarizing factor (ADHF) from mesenteric artery perivascular adipose tissue: involvement of myocyte BKCa channels and adiponectin.

British journal of pharmacology·2013
Same author

Obesity, diabetes and atrial fibrillation; epidemiology, mechanisms and interventions.

Current cardiology reviews·2012
Same author

Relationship of endothelial function and atherosclerosis to treatment response in late-life depression.

International journal of geriatric psychiatry·2012
Same author

International Society of Hypertension Low and Middle Income Countries Committee: Review of the goals of the Committee and of 5 years of ISH activities in low and middle income countries.

Journal of hypertension·2010

Area of Science:

  • Cardiovascular Medicine
  • Vascular Biology
  • Hypertension Research

Background:

  • Hypertension is a major risk factor for cardiovascular diseases.
  • Current antihypertensive treatments have limited success in reducing cardiac mortality.
  • Vascular structural changes, including vessel hypertrophy, contribute to cardiac event risk.

Purpose of the Study:

  • To highlight the critical role of vascular structural changes in hypertension-related cardiovascular risk.
  • To emphasize the need for therapeutic strategies that address vascular remodeling beyond blood pressure reduction.

Main Methods:

  • Review of existing literature on hypertension, cardiovascular disease, and vascular structure.
  • Analysis of the impact of structural vascular alterations on cardiac events.
  • Synthesis of findings to inform future therapeutic approaches.

Main Results:

  • Structural changes in resistance vessels, aorta, and left ventricle are significant risk factors for premature cardiac events.
  • Lowering blood pressure alone is insufficient to mitigate all cardiovascular risks associated with hypertension.
  • Vascular hypertrophy is a key pathological feature linked to increased cardiac risk.

Conclusions:

  • Future antihypertensive therapies must incorporate strategies to reverse vascular structural alterations.
  • Addressing vascular remodeling is crucial for improving outcomes in hypertensive patients.
  • A comprehensive approach targeting both blood pressure and vascular structure is necessary for effective cardiovascular risk reduction.

Related Experiment Videos