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[Prevalence of hyperimmunization against tetanus and systematic adverse reactions to tetanus toxoid in children]

Leszek Szenborn1, Elzbieta Saraczyńska, Lucjan Ilnicki

  • 1Katedra i Klinika Pediatrii i Chorób Infekcyjnych, Akademii Medycznej we Wrocławiu. szenborn@zak.am.wroc.pl

Medycyna Wieku Rozwojowego
|May 8, 2009
PubMed

Insights

Children in Poland exhibit robust tetanus immunity, with very few experiencing adverse reactions to the tetanus vaccine. Antibody levels indicate strong protection, suggesting a low risk of severe side effects from tetanus toxoid immunization.

Area of Science:

  • Immunology
  • Vaccinology

Context:

  • Systemic reactions to tetanus vaccine are rare, with adverse events potentially linked to excessive antibody titers.
  • Understanding tetanus antibody concentrations is crucial for assessing the risk of post-vaccination side effects.

Purpose:

  • To investigate tetanus antibody concentrations in children to define the risk of adverse reactions.
  • To evaluate the relationship between tetanus toxoid antibody levels and potential side effects.

Summary:

  • A study examined 190 children aged 7 and 14 years for tetanus antibody concentrations using commercial EIA.
  • All participants demonstrated protective antibody levels (≥0.01 IU/ml), with higher concentrations observed in 14-year-olds compared to 7-year-olds.
  • A small percentage (6.84%) had high antibody levels (>5 IU/ml), potentially increasing side effect risk if revaccinated within five years.

Impact:

  • Tetanus immunity in Polish children is assessed as very good, indicating a low risk of severe side effects from tetanus vaccination.
  • Findings suggest that current tetanus vaccination schedules provide effective and lasting immunity in the pediatric population.
Abstract

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