Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Yeast Signaling

Yeast Signaling

Yeasts are single-celled organisms, but unlike bacteria, they are eukaryotes (cells with a nucleus). Cell signaling in yeast is similar to signaling in other eukaryotic cells. A ligand, such as a protein or a small molecule released from a yeast cell, attaches to a receptor on the cell surface. The binding stimulates second-messenger kinases to activate or inactivate transcription factors that further regulate gene expression. Many of the yeast intracellular signaling cascades have similar...

Microbes in Beverage Production

Microbes in Beverage Production

Alcoholic beverages such as wine, beer, and spirits are the products of microbial fermentation processes that transform simple sugars into ethanol and a wide array of complex flavor compounds. These transformations rely on the metabolic activities of specific yeasts and bacteria, which are selected and controlled to yield the desired beverage characteristics.Wine Fermentation and MaturationWine production begins with the crushing of grapes to release juice and pulp, forming a must that is...

Bioreactor Controls-III

Bioreactor Controls-III

Strain improvement is a foundational strategy in industrial microbiology aimed at maximizing microbial productivity, particularly because natural isolates typically yield commercially valuable products in very low concentrations. Although optimizing the culture medium and environmental conditions can improve yields, these adjustments are inherently limited by the organism’s genetic potential. As a result, the focus shifts toward genetic modifications to enhance biosynthetic capacity. The...

Mouse Models of Cancer Study

Mouse Models of Cancer Study

Mice have long served as models for studying human biology and pathology because of their phylogenetic and physiological similarity with humans. They are also easy to maintain and breed in the laboratory, and hence, many inbred strains are now available for research. Studies on mice have contributed immeasurably to our understanding of cancer biology.
The development of transgenic, knockout, and knock-in mice has led to an exponential increase in their use as model organisms in research,...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Apparent Epigenetic Meiotic Double-Strand-Break Disparity in Saccharomyces cerevisiae: A Meta-Analysis.

Genetics·2016

Same author

The roles of the Saccharomyces cerevisiae RecQ helicase SGS1 in meiotic genome surveillance.

PloS one·2010

Same author

Separable roles for Exonuclease I in meiotic DNA double-strand break repair.

DNA repair·2010

Same author

Distinct regulation of Mlh1p heterodimers in meiosis and mitosis in Saccharomyces cerevisiae.

Genetics·2010

Same author

Temperature-dependent modulation of chromosome segregation in msh4 mutants of budding yeast.

PloS one·2009

Same author

Interaction of genetic and environmental factors in Saccharomyces cerevisiae meiosis: the devil is in the details.

Methods in molecular biology (Clifton, N.J.)·2009

Search research articles

Related Experiment Video

Updated: Jun 23, 2026

Transformation of Probiotic Yeast and Their Recovery from Gastrointestinal Immune Tissues Following Oral Gavage in Mice

Transformation of Probiotic Yeast and Their Recovery from Gastrointestinal Immune Tissues Following Oral Gavage in Mice

Published on: February 8, 2016

The new yeast is a mouse.

Rhona H Borts¹

¹Department of Genetics, University of Leicester, Leicester,United Kingdom. rhb7@leicester.ac.uk

|May 8, 2009

Summary

This summary is machine-generated.

Genomic recombination hotspots are influenced by both nearby DNA sequences and distant regulatory elements acting in cis and trans. Understanding these distant factors is crucial for mapping recombination patterns.

More Related Videos

A Contemporary Warming/Restraining Device for Efficient Tail Vein Injections in a Murine Fungal Sepsis Model

A Contemporary Warming/Restraining Device for Efficient Tail Vein Injections in a Murine Fungal Sepsis Model

Published on: November 6, 2020

Infecting Mice with Malassezia spp. to Study the Fungus-Host Interaction

Infecting Mice with Malassezia spp. to Study the Fungus-Host Interaction

Published on: November 6, 2019

Related Experiment Videos

Last Updated: Jun 23, 2026

Transformation of Probiotic Yeast and Their Recovery from Gastrointestinal Immune Tissues Following Oral Gavage in Mice

Transformation of Probiotic Yeast and Their Recovery from Gastrointestinal Immune Tissues Following Oral Gavage in Mice

Published on: February 8, 2016

A Contemporary Warming/Restraining Device for Efficient Tail Vein Injections in a Murine Fungal Sepsis Model

A Contemporary Warming/Restraining Device for Efficient Tail Vein Injections in a Murine Fungal Sepsis Model

Published on: November 6, 2020

Infecting Mice with Malassezia spp. to Study the Fungus-Host Interaction

Infecting Mice with Malassezia spp. to Study the Fungus-Host Interaction

Published on: November 6, 2019

Area of Science:

Genetics
Molecular Biology
Genomics

Background:

Recombination hotspots are specific genomic regions with elevated rates of DNA recombination.
The regulation of recombination hotspots is complex and not fully understood.
Both local and distant genomic sequences are implicated in controlling recombination frequencies.

Purpose of the Study:

To investigate the influence of distant genomic sequences on recombination hotspots.
To determine the roles of cis-acting and trans-acting elements in recombination hotspot regulation.

Main Methods:

Analysis of genomic data to identify correlations between distant sequences and recombination rates.
Computational modeling to assess the impact of cis and trans elements.

Main Results:

Recombination hotspots are significantly influenced by sequences located far from the hotspot itself.
Both cis-acting elements (on the same DNA molecule) and trans-acting elements (on other DNA molecules or via regulatory factors) play a role.
The interplay between local and distant sequences dictates hotspot activity.

Conclusions:

Recombination hotspot determination is a multi-faceted process involving long-range genomic interactions.
Future research should consider both local and distant genomic contexts for a comprehensive understanding of recombination.