Related Experiment Video
Updated: Jun 23, 2026

Breast Milk Enhances Growth of Enteroids: An Ex Vivo Model of Cell Proliferation
Published on: February 15, 2018
Effects of formula supplementation in breast-fed infants with failure to thrive
Irena Hren1, Natasa Fidler Mis, Jernej Brecelj
1Dietetics and Nutrition Unit, University Medical Centre, Ljubljana, Slovenia.
Insights
Formula supplementation improved growth in infants with failure to thrive, maintaining breastfeeding in most cases. This intervention offers a viable option for enhancing infant weight gain without compromising the breastfeeding relationship.
Area of Science:
- Pediatrics
- Infant Nutrition
- Growth Monitoring
Background:
- Infants with failure to thrive often present with underweight and require nutritional support.
- Assessing the impact of formula supplementation on growth while preserving breastfeeding is crucial.
Purpose of the Study:
- To evaluate if formula supplementation can improve underweight in infants experiencing failure to thrive.
- To determine if breastfeeding can be maintained during formula supplementation.
Main Methods:
- A prospective intervention study involved 31 exclusively breast-fed infants diagnosed with failure to thrive.
- Infants received ad libitum infant formula after each breastfeeding session, with continued breastfeeding support.
Main Results:
- Daily energy intake significantly increased with formula supplementation.
- While human milk intake decreased, 81% of infants continued partial or full breastfeeding.
- Supplementation over 31 days resulted in significant improvements in weight, length, and head circumference standard deviation scores.
Conclusions:
- Formula supplementation is an effective method to improve growth in infants with failure to thrive.
- This approach successfully enhanced growth in 72% of participants while preserving breastfeeding in the majority.
Background:
The aim of the present study was to assess whether formula supplementation of infants with failure to thrive can improve underweight without jeopardizing breast-feeding.
Methods:
In a prospective intervention study 31 term exclusively breast-fed infants were studied, who were admitted to hospital at an age of 28-99 days with failure to thrive (< or =40% expected weight gain for age and/or bodyweight < or =10th percentile for age) without underlying disease. Infant formula was offered ad libitum after each breast-feeding, while continued breast-feeding was supported.
Results:
Energy intake per day increased from 352 +/- 111 kJ/kg (mean +/- SD) at study start to 587 +/- 115 kJ/kg (P < 0.001, days 1-3 of supplementation) and 501 +/- 99 kJ/kg (days 29-31; P < 0.001 vs study entry). Twenty-five infants continued to be partially (n = 21) or fully (n = 4) breast-fed. Human milk intake decreased from 476 +/- 163 g/day (study days 1-3) to 349 +/- 285 g/day (study days 29-31; P < 0.01). The contribution of breast milk to total milk intake decreased from 100% to 42 +/- 35% (P < 0.001). Supplementation over 31 days led to increased weight (0.98 [0.70], standard deviation scores [SDS]), length (+0.40 [0.41] SDS) and head circumference (+0.59 [0.93] SDS).
Conclusions:
One month of formula supplementation successfully improved growth in 72% of infants with failure to thrive on human milk feeding. Breast-feeding was maintained in 81% of infants.
Related Concept Videos
Drug Dosing: Infants and Children
Nature and Nurture
Development of Human Microbiota
Oxygen Requirements and Growth Patterns
Enteral Nutrition II: Nasointestinal and Gastrostomy Feeding
Nasointestinal Feeding
Nasointestinal feeding involves placing a tube through...
Teratogenicity
