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Association between serum adipocytokine and cholesterol levels in cord blood

Yuya Nakano1, Kazuo Itabashi, Takeshi Maruyama

  • 1Department of Pediatrics, Showa University School of Medicine, Tokyo, Japan. nakano-yt@tulip.sannet.ne.jp

Pediatrics International : Official Journal of the Japan Pediatric Society
|May 8, 2009
PubMed

Insights

Cord blood leptin, a hormone, is linked to infant cholesterol levels and gender at birth. This finding suggests leptin may regulate fetal lipid metabolism.

Area of Science:

  • Neonatal physiology
  • Endocrinology
  • Metabolic research

Background:

  • Serum leptin and adiponectin are linked to adult lipid metabolism.
  • These adipocytokines influence fetal growth, but their association with cord blood cholesterol is unclear.

Purpose of the Study:

  • To investigate the association between cord blood adipocytokine levels (leptin and adiponectin) and cholesterol levels at birth.
  • To explore relationships with neonatal characteristics and maternal factors.

Main Methods:

  • Analysis of cord blood samples from 52 appropriate-for-gestational-age infants.
  • Measurement of leptin, adiponectin, total cholesterol (TC), and low-density lipoprotein cholesterol (LDL-C).
  • Assessment of neonatal characteristics and maternal factors, with regression analyses.

Main Results:

  • Cord blood leptin levels were higher in female infants.
  • Leptin associated with birthweight, gestational age, BMI, LDL-C, and TC.
  • Multiple regression showed leptin linked to BMI, LDL-C, and gender; adiponectin linked to gestational age.

Conclusions:

  • Cord leptin levels correlate significantly with cord cholesterol, anthropometry, and infant gender.
  • Cord blood leptin may play a crucial role in fetal lipid metabolism regulation.
Abstract

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