Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Replication in Eukaryotes01:29

Replication in Eukaryotes

In eukaryotic cells, DNA replication is highly conserved and tightly regulated. Multiple linear chromosomes must be duplicated with high fidelity before cell division, so there are many proteins that fulfill specialized roles in the replication process. Replication occurs in three phases: initiation, elongation, and termination, and ends with two complete sets of chromosomes in the nucleus.
Many Proteins Orchestrate Replication at the Origin
Eukaryotic replication follows many of the same...
Replication in Eukaryotes02:31

Replication in Eukaryotes

Overview
Telomeres and Telomerase02:41

Telomeres and Telomerase

In eukaryotic DNA replication, a single-stranded DNA fragment remains at the end of a chromosome after the removal of the final primer. This section of DNA cannot be replicated in the same manner as the rest of the strand because there is no 3’ end to which the newly synthesized DNA can attach. This non-replicated fragment results in gradual loss of the chromosomal DNA during each cell duplication. Additionally, it can induce a DNA damage response by enzymes that recognize single-stranded DNA.
Telomeres and Telomerase02:41

Telomeres and Telomerase

In eukaryotic DNA replication, a single-stranded DNA fragment remains at the end of a chromosome after the removal of the final primer. This section of DNA cannot be replicated in the same manner as the rest of the strand because there is no 3’ end to which the newly synthesized DNA can attach. This non-replicated fragment results in gradual loss of the chromosomal DNA during each cell duplication. Additionally, it can induce a DNA damage response by enzymes that recognize single-stranded DNA.
Maintenance of the ES Cell State01:14

Maintenance of the ES Cell State

The cells of the blastocyst inner cell mass only remain pluripotent for a short time. This state of pluripotency and self-renewal can be maintained in embryonic stem (ES) cell culture by adding specific chemicals or growth factors to ensure the cells can continue dividing and later differentiate into different cell types. In some cases, the cells are grown on a feeder layer of differentiated cells, which provides the growth factors and extracellular matrix components necessary for stem cell...
Replicative Cell Senescence02:15

Replicative Cell Senescence

Replicative cell senescence is a property of cells that allows them to divide a finite number of times throughout the organism's lifespan while preventing excessive proliferation. Replicative senescence is associated with the gradual loss of the telomere — short, repetitive DNA sequences found at the end of the chromosomes. Telomeres are bound by a group of proteins to form a protective cap on the ends of chromosomes. Embryonic stem cells express telomerase — an enzyme that adds the telomeric...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Alzheimer's Protection by PLCγ2 Compacts Plaques, Redistributes Microglia, and Protects Synapses in App<sup>NL</sup> <sup>-G-F</sup> Mice.

Glia·2026
Same author

Lessons Learned from Co-Creating a Clinician Educator Track.

Academic psychiatry : the journal of the American Association of Directors of Psychiatric Residency Training and the Association for Academic Psychiatry·2026
Same author

TeloNet is born: why all specialities need to be aware of telomere biology disorders.

Frontiers in medicine·2026
Same author

Telomere Dysfunction and Proteostasis Decline Define Distinct Pathways of Cellular Senescence in the Human Respiratory Tract.

Aging cell·2026
Same author

Mitotic microhomology-mediated break-induced replication promotes chromoanasynthesis.

Nature communications·2026
Same author

Perceptions, Use, and Barriers of Clozapine Therapeutic Drug Monitoring in the United States: A Multidisciplinary Survey Study.

Therapeutic drug monitoring·2025

Related Experiment Video

Updated: Jun 23, 2026

Telomere Length and Telomerase Activity; A Yin and Yang of Cell Senescence
12:08

Telomere Length and Telomerase Activity; A Yin and Yang of Cell Senescence

Published on: May 22, 2013

Telomere length maintenance in stem cell populations.

Nicholas D Allen1, Duncan M Baird

  • 1School of Biosciences, Cardiff University, Cardiff CF10 3, UK.

Biochimica Et Biophysica Acta
|May 8, 2009
PubMed
Summary

Telomere length maintenance is crucial for genome integrity and tissue homeostasis. Human embryonic stem cells show more stable telomeres, potentially impacting cancer suppression and tissue repair.

Area of Science:

  • Genomics
  • Stem Cell Biology
  • Cancer Research

Background:

  • Telomere length maintenance is vital for genome integrity and cellular function.
  • Stem cell telomere dynamics balance tissue homeostasis with tumor suppression.
  • Telomere erosion acts as a proliferative lifespan barrier against cancer.

Purpose of the Study:

  • To review current understanding of telomere dynamics in stem cells.
  • To investigate telomere stability in human embryonic stem cells.
  • To explore the role of telomere dynamics in the homeostasis-tumor suppression balance.

Main Methods:

  • Literature review on telomere dynamics in stem cells.
  • Analysis of telomere stability in human embryonic stem cells.
  • Comparison of telomere dynamics across different cell types.

More Related Videos

Optimization of Performance Parameters of the TAGGG Telomere Length Assay
08:23

Optimization of Performance Parameters of the TAGGG Telomere Length Assay

Published on: April 21, 2023

Utilizing Murine Inducible Telomerase Alleles in the Studies of Tissue Degeneration/Regeneration and Cancer
08:34

Utilizing Murine Inducible Telomerase Alleles in the Studies of Tissue Degeneration/Regeneration and Cancer

Published on: April 13, 2015

Related Experiment Videos

Last Updated: Jun 23, 2026

Telomere Length and Telomerase Activity; A Yin and Yang of Cell Senescence
12:08

Telomere Length and Telomerase Activity; A Yin and Yang of Cell Senescence

Published on: May 22, 2013

Optimization of Performance Parameters of the TAGGG Telomere Length Assay
08:23

Optimization of Performance Parameters of the TAGGG Telomere Length Assay

Published on: April 21, 2023

Utilizing Murine Inducible Telomerase Alleles in the Studies of Tissue Degeneration/Regeneration and Cancer
08:34

Utilizing Murine Inducible Telomerase Alleles in the Studies of Tissue Degeneration/Regeneration and Cancer

Published on: April 13, 2015

Main Results:

  • Human embryonic stem cells exhibit greater telomere stability.
  • Reduced susceptibility to large-scale stochastic telomeric deletions observed.
  • Telomere dynamics are critical for balancing cell proliferation and cancer prevention.

Conclusions:

  • Telomere stability in human embryonic stem cells is a key finding.
  • These findings have implications for understanding aging, cancer, and regenerative medicine.
  • Further research into telomere dynamics can elucidate mechanisms of disease and aging.