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Updated: Jun 23, 2026

Quantifying Subcellular Ubiquitin-proteasome Activity in the Rodent Brain
Published on: May 21, 2019
A critical evaluation of the ubiquitin-proteasome system in Parkinson's disease
Casey Cook1, Leonard Petrucelli
1Department of Neuroscience, Mayo Clinic, Jacksonville, FL 32224, USA.
Abstract:
The evidence for impairment in the ubiquitin proteasome system (UPS) in Parkinson's disease (PD) is mounting and becoming increasingly more convincing. However, it is presently unclear whether UPS dysfunction is a cause or result of PD pathology, a crucial distinction which impedes both the understanding of disease pathogenesis and the development of effectual therapeutic approaches. Recent findings discussed within this review offer new insight and provide direction for future research to conclusively resolve this debate.
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