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Updated: Jun 23, 2026

Stromal Cell Isolation From Hematopoietic Organs
Published on: January 26, 2024
Aging of marrow stromal (skeletal) stem cells and their contribution to age-related bone loss
Ilaria Bellantuono1, Abdullah Aldahmash, Moustapha Kassem
1University of Sheffield Medical School, Sheffield S10 2RX, UK. i.bellantuono@shef.ac.uk
Abstract:
Marrow stromal cells (MSC) are thought to be stem cells with osteogenic potential and therefore responsible for the repair and maintenance of the skeleton. Age related bone loss is one of the most prevalent diseases in the elder population. It is controversial whether MSC undergo a process of aging in vivo, leading to decreased ability to form and maintain bone homeostasis with age. In this review we summarize evidence of MSC involvement in age related bone loss and suggest new emerging targets for intervention.
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