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Pain is critical to various clinical pathologies, provoking an urgent need for effective management. Pain, whether acute or chronic, is a complex neurochemical process. Its alleviation depends on the type, with nonopioid analgesics effective for mild to moderate pain, such as musculoskeletal or inflammatory pain, while neuropathic pain responds best to anticonvulsants, tricyclic antidepressants, or serotonin/norepinephrine reuptake inhibitors. For severe acute or chronic pain, opioids may be...
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Related Experiment Video

Updated: Jun 23, 2026

Autoradiographic Measurements of [14C]-Iodoantipyrine in Rat Brain Following Central Post-Stroke Pain
07:27

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Published on: July 18, 2016

Central post-stroke pain: current evidence.

Gyanendra Kumar1, Chetan Rasiklal Soni

  • 1Department of Neurology, University of Missouri-Healthcare Columbia, Columbia, Missouri, USA. kumargy@health.missouri.edu

Journal of the Neurological Sciences
|May 8, 2009
PubMed
Summary
This summary is machine-generated.

Central post-stroke pain (CPSP) is reviewed, covering its definition, occurrence, causes, brain structures involved, symptoms, and therapies. This condition significantly impacts stroke survivors, necessitating effective management strategies.

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Area of Science:

  • Neurology
  • Pain Medicine
  • Neuroscience

Background:

  • Central post-stroke pain (CPSP) is a debilitating neuropathic pain condition arising after a stroke.
  • Understanding CPSP's complex etiology and clinical manifestations is crucial for effective patient care.

Purpose of the Study:

  • To provide a comprehensive review of the current knowledge on central post-stroke pain.
  • To synthesize evidence regarding the definition, epidemiology, pathophysiology, neuroanatomy, clinical features, and treatment of CPSP.

Main Methods:

  • Systematic literature review of existing research on central post-stroke pain.
  • Analysis of studies focusing on CPSP definition, epidemiology, and pathophysiology.
  • Evaluation of evidence concerning neuroanatomy, clinical presentation, and therapeutic interventions.

Main Results:

  • CPSP is characterized by specific neuropathic pain symptoms following cerebrovascular events.
  • Epidemiological data indicate a significant prevalence of CPSP among stroke survivors.
  • Current evidence highlights diverse pathophysiological mechanisms and neuroanatomical correlates.

Conclusions:

  • Central post-stroke pain requires a thorough understanding of its multifaceted aspects.
  • Further research is needed to refine diagnostic criteria and optimize treatment strategies for CPSP.
  • Multidisciplinary approaches are essential for managing the complex needs of patients with central post-stroke pain.