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Related Experiment Video

Updated: Jun 23, 2026

Improving Strength, Power, Muscle Aerobic Capacity, and Glucose Tolerance through Short-term Progressive Strength Training Among Elderly People

Improving Strength, Power, Muscle Aerobic Capacity, and Glucose Tolerance through Short-term Progressive Strength Training Among Elderly People

Published on: July 5, 2017

EAA supplementation to increase nitrogen intake improves muscle function during bed rest in the elderly.

Arny A Ferrando¹, Doug Paddon-Jones, Nicholas P Hays

¹University of Arkansas for Medical Sciences, USA. aferrando@uams.edu

Clinical Nutrition (Edinburgh, Scotland)

|May 8, 2009

Summary

Essential amino acid (EAA) supplementation may preserve muscle function in older adults during hospitalization. This intervention helps maintain physical function during prolonged inactivity, unlike standard protein intake.

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A Preclinical Model of Sepsis-Induced Myopathy with Disuse in Mice

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Improving Strength, Power, Muscle Aerobic Capacity, and Glucose Tolerance through Short-term Progressive Strength Training Among Elderly People

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Published on: July 5, 2017

A Preclinical Model of Sepsis-Induced Myopathy with Disuse in Mice

A Preclinical Model of Sepsis-Induced Myopathy with Disuse in Mice

Published on: June 14, 2024

Area of Science:

Gerontology
Nutritional Science
Muscle Physiology

Background:

Older adults face prolonged hospitalization and protein malnutrition, leading to functional decline.
Increased protein intake improves nitrogen balance but its effect on function remains unclear.
Compulsory inactivity during hospitalization exacerbates functional loss in the elderly.

Purpose of the Study:

To investigate the impact of essential amino acid (EAA) supplementation on lean body mass (LBM) and muscle function.
To assess the effects of increased protein intake via EAA supplementation in older individuals undergoing bed rest.

Main Methods:

10-day bed rest study involving older adults.
Participants received either a placebo or 15g of essential amino acids (EAA) thrice daily.
Lean body mass (LBM), muscle protein synthesis, and muscle function were measured pre- and post-bed rest.
Repeated measures analysis of covariance (RMANCOVA) was used for statistical analysis, accounting for gender and baseline measures.

Main Results:

Essential amino acid (EAA) supplementation showed potential in preserving functional outcomes.
Preliminary analysis suggests a positive effect of EAA on maintaining physical function.

Conclusions:

Supplementing protein intake above the Recommended Dietary Allowance (RDA) may preserve muscle function in elderly individuals during inactivity.
Essential amino acid (EAA) supplementation offers an effective strategy to increase protein intake without impacting satiety.
This approach could be beneficial for hospitalized elderly patients experiencing enforced inactivity.