Related Experiment Video
Updated: Jun 23, 2026

Efficacy of Fu's Subcutaneous Needling on Sciatic Nerve Pain: Behavioral and Electrophysiological Changes in a Chronic Constriction Injury Rat Model
Published on: June 30, 2023
Intraneural injection during nerve stimulator-guided sciatic nerve block at the popliteal fossa
X Sala Blanch1, A M López, J Carazo
1Department of Anesthesiology, Hospital Clinic, Universitat de Barcelona, C/Villarroel 170, Barcelona 08036, Spain. xsala@clinic.ub.es
Intraneural injection during nerve stimulator-guided sciatic nerve blocks is common, occurring in 66% of patients. However, this common intraneural injection does not necessarily lead to neurological complications.
Area of Science:
- Anesthesiology
- Regional Anesthesia
- Ultrasound-Guided Procedures
Background:
- The precise needle tip location during nerve stimulation-guided peripheral nerve blocks remains uncertain.
- This study investigated the frequency of intraneural injection during nerve stimulator-guided sciatic nerve blocks in the popliteal fossa using high-frequency ultrasound.
Purpose of the Study:
- To test the hypothesis that intraneural injection is a frequent event during nerve stimulator-guided sciatic nerve blocks in the popliteal fossa.
- To assess the incidence of intraneural injection and its association with neurological outcomes.
Main Methods:
- Forty-two patients undergoing hallux valgus repair received a sciatic nerve block guided by nerve stimulation.
- Ultrasound imaging was used to measure sciatic nerve area before and after local anesthetic injection, assessing for nerve swelling and local anesthetic spread.
- Intraneural injection was defined by a significant increase in nerve area (>15%) and additional ultrasonographic markers.
Main Results:
- A nerve area increase of ≥15% was observed in 76% of patients post-injection.
- Nerve swelling with fascicular separation occurred in 88% of patients, and local anesthetic spread was noted proximally (14%) and distally (38%).
- Intraneural injection criteria were met in 66% of patients, with greater nerve area increase associated with faster block onset.
Conclusions:
- Intraneural injection is a common occurrence during nerve stimulator-guided sciatic nerve blocks in the popliteal fossa.
- Despite the high incidence of intraneural injection, no neurological complications were observed in the study cohort.
- These findings suggest that intraneural injection may not invariably result in adverse neurological outcomes.
Related Concept Videos
Local Anesthetics: Clinical Application as Intravenous Regional Anesthesia
One of the advantages of...
Local Anesthetics: Clinical Application as Spinal Anesthesia
Local Anesthetics: Clinical Application as Surface, Infiltration, and Conduction Block Anesthesia
