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Related Experiment Video

Updated: Jun 23, 2026

High-resolution Structural Magnetic Resonance Imaging of the Human Subcortex In Vivo and Postmortem

High-resolution Structural Magnetic Resonance Imaging of the Human Subcortex In Vivo and Postmortem

Published on: December 30, 2015

Function-based intersubject alignment of human cortical anatomy.

Mert R Sabuncu¹, Benjamin D Singer, Bryan Conroy

¹Department of Electrical Engineering, Princeton University, Princeton, NJ 08544, USA.

Cerebral Cortex (New York, N.Y. : 1991)

|May 8, 2009

Summary

This summary is machine-generated.

This study introduces a novel method for aligning individual human brains based on neural activity patterns during movie viewing. This approach enhances understanding of functional neuroanatomy and brain variability across individuals.

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Translational Brain Mapping at the University of Rochester Medical Center: Preserving the Mind Through Personalized Brain Mapping

Translational Brain Mapping at the University of Rochester Medical Center: Preserving the Mind Through Personalized Brain Mapping

Published on: August 12, 2019

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Last Updated: Jun 23, 2026

High-resolution Structural Magnetic Resonance Imaging of the Human Subcortex In Vivo and Postmortem

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Published on: December 30, 2015

Midface Hypoplasia and Cranial Base Morphology in Syndromic Craniosynostosis: A Comparative Analysis Study Using a Predictive Regression Model

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Published on: November 4, 2025

Translational Brain Mapping at the University of Rochester Medical Center: Preserving the Mind Through Personalized Brain Mapping

Translational Brain Mapping at the University of Rochester Medical Center: Preserving the Mind Through Personalized Brain Mapping

Published on: August 12, 2019

Area of Science:

Neuroscience
Brain Imaging
Functional Neuroanatomy

Background:

Understanding human brain functional neuroanatomy requires methods to map individual brains to population variability.
Current methods often rely on predefined functionally defined areas, limiting precision.

Purpose of the Study:

To develop and validate a new method for aligning functional neuroanatomy across individuals.
To improve the analysis of functional brain organization by considering spatial patterns of neural activity.

Main Methods:

Developed a novel alignment method based on spatial patterns of neural activity elicited by viewing a movie.
Implemented the method on a two-dimensional manifold of an inflated, spherical cortical surface.
Validated the method using data from viewing static images of objects and faces.

Main Results:

The new alignment method successfully maps functional neuroanatomy across individuals.
The method generalizes to different cognitive activation paradigms beyond movie viewing.
Improved group statistics in a general linear model (GLM) analysis for image viewing data.

Conclusions:

This novel alignment technique offers a more robust way to study functional neuroanatomy and individual brain variability.
The method's success with diverse stimuli suggests broad applicability in neuroimaging research.
Enhances the ability to make conclusions about human brain organization by accounting for individual differences.