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Higher sensitivity and specificity for diffusion-weighted imaging of malignant lung lesions without apparent
Tomohiro Uto1, Yasuo Takehara, Yutaro Nakamura
1Second Division, Department of Internal Medicine, Hamamatsu University School of Medicine, 1-20-1 Handayama, Hamamatsu 431-3192, Japan.
Radiology
|May 8, 2009
Summary
Signal intensity ratio (LSR) effectively differentiates lung cancer from benign nodules on diffusion-weighted MRI. This method shows higher accuracy than apparent diffusion coefficient (ADC) for lung nodule diagnosis.
Area of Science:
- Radiology
- Oncology
- Medical Imaging
Background:
- Pulmonary nodules require accurate differentiation between benign and malignant types.
- Diffusion-weighted magnetic resonance (DW MR) imaging offers potential for characterizing lung lesions.
Purpose of the Study:
- To compare the efficacy of apparent diffusion coefficient (ADC) and lesion-to-spinal cord ratio (LSR) in distinguishing lung cancer from benign lesions.
- To evaluate the diagnostic performance of LSR and ADC on high-b value DW MR images.
Main Methods:
- Prospective review of 28 patients with pulmonary nodules.
- Analysis of signal intensities of lesions and spinal cord on DW MR images (b=1000 sec/mm²).
- Calculation of ADC and measurement of LSR for each lesion.
Main Results:
- LSR was significantly higher in cancer nodules compared to benign lesions (P<0.05).
- ADC values did not show significant differences between benign and malignant nodules.
- Receiver operating characteristic analysis revealed a higher area under the curve for LSR (0.911) than for ADC (0.600).
Conclusions:
- LSR measurement on high-b value DW imaging is a promising method for differentiating benign from malignant lung nodules.
- LSR demonstrates superior diagnostic performance compared to ADC in this context.
