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Updated: Jun 23, 2026

A Computational Modeling Approach to Investigate the Influence of Hyperthermia on the Tumor Microenvironment
Published on: December 1, 2023
Modeling time variation of blood temperature in a bioheat equation and its application to temperature analysis due to
Akimasa Hirata1, Osamu Fujiwara
1Department of Computer Science and Technology, Nagoya Institute of Technology, Nagoya, Japan. ahirata@nitech.ac.jp
Abstract:
The present study discusses a scheme to take into account core temperature variation in a well-known bioheat equation. First, the limitation in conventional modeling of the bioheat equation was investigated for a problem in which the whole-body phantom should be taken into account. Then, schemes for varying body-core temperature in the bioheat equation were discussed for radio-frequency exposures. The computational uncertainty in the core temperature elevation was found to be reasonable when a proper scheme for computing the net rate of heat acquisition by blood from body tissue was introduced.
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