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Enhancement of chemically-induced HL-60 cell differentiation by 3,3'-diindolylmethane derivatives
Tomomi Noguchi-Yachide1, Masashi Tetsuhashi, Hiroshi Aoyama
1Institute of Molecular & Cellular Biosciences, The University of Tokyo, Tokyo, Japan. noguchi@iam.u-tokyo.ac.jp
Chemical & Pharmaceutical Bulletin
|May 8, 2009
Abstract:
3,3'-Diindolylmethane (DIM, 1) and its derivatives have been prepared, and their enhancing effects on chemically-induced HL-60 cell differentiation were analyzed. Among the prepared compounds, IndDIM (12) showed the most potent enhancing effect on HL-60 cell differentiation induced by chemicals, including retinoids, 1,25-dihydroxyvitamin D(3), 12-O-tetradecanoyl phorbol-13-acetate and dimethyl sulfoxide.
