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Updated: Jun 23, 2026

Nerve Excitability Assessment in Chemotherapy-induced Neurotoxicity

Nerve Excitability Assessment in Chemotherapy-induced Neurotoxicity

Published on: April 26, 2012

Delayed oxaliplatin-induced sensorimotor polyneuropathy.

Raffaele Nardone¹, Thomas Buratti, Stefan Golaszewski

¹Department of Neurology, Franz Tappeiner Hospital, Via Rossini 5, Meran (BZ), Italy. raffaele.nardone@asbmeran-o.it

|May 8, 2009

Summary

This summary is machine-generated.

Delayed polyneuropathy after oxaliplatin chemotherapy is a rare but documented condition. Electrophysiological studies confirm this neurotoxicity, revealing mixed axonal and demyelinating patterns in affected patients.

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Last Updated: Jun 23, 2026

Nerve Excitability Assessment in Chemotherapy-induced Neurotoxicity

Nerve Excitability Assessment in Chemotherapy-induced Neurotoxicity

Published on: April 26, 2012

Area of Science:

Neurology
Oncology
Clinical Electrophysiology

Background:

Oxaliplatin chemotherapy is associated with rare cases of delayed polyneuropathy.
The clinical and electrophysiological characteristics of this neurotoxicity remain poorly documented.

Observation:

Four patients developed peripheral neuropathy months after completing oxaliplatin treatment.
Nerve conduction studies were performed to assess neurotoxicity.

Findings:

All patients exhibited abnormal sensory nerve conduction.
Two patients showed evidence of a mixed axonal and demyelinating sensorimotor polyneuropathy.

Implications:

Electrophysiological studies can confirm delayed polyneuropathy following oxaliplatin chemotherapy.
This finding aids in understanding and diagnosing oxaliplatin-induced neurotoxicity.