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Updated: Jun 23, 2026

Nerve Excitability Assessment in Chemotherapy-induced Neurotoxicity
Published on: April 26, 2012
Delayed oxaliplatin-induced sensorimotor polyneuropathy
Raffaele Nardone1, Thomas Buratti, Stefan Golaszewski
1Department of Neurology, Franz Tappeiner Hospital, Via Rossini 5, Meran (BZ), Italy. raffaele.nardone@asbmeran-o.it
Background:
To date, only a few cases have been reported that indicate that a delayed polyneuropathy may occur after chemotherapy with oxaliplatin. The clinical and electrophysiological manifestations of this delayed neurotoxicity have never been well documented.
Case Reports:
Nerve conduction studies were performed in 4 patients who developed acute peripheral neuropathy several months after completion of oxaliplatin-containing chemotherapy. Sensory nerve conduction was abnormal in all patients. In 2 patients, the electrodiagnostic studies showed a mixed axonal and demyelinating sensorimotor polyneuropathy.
Conclusions:
Delayed polyneuropathy occurring after oxaliplatin-based chemotherapy can be confirmed by electrophysiological studies.
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