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Updated: Jun 23, 2026
12:03
In Vivo Model for Testing Effect of Hypoxia on Tumor Metastasis
Published on: December 9, 2016
Bone tumors: osteosarcoma and Ewing's sarcoma
Travis Heare1, Mary A Hensley, Shelley Dell'Orfano
1Musculoskeletal Tumor Program, Department of Orthopaedic Surgery, University of Colorado, The Children's Hospital, Denver, CO, USA. heare.travis@tchden.org
Current Opinion in Pediatrics
|May 8, 2009
Summary
Pediatric osteosarcoma and Ewing sarcoma treatments have improved, increasing survival rates. This review covers current treatments, reconstructive options, and long-term outcomes for childhood bone cancers.
Area of Science:
- Pediatric Oncology
- Orthopedic Oncology
- Surgical Reconstruction
Background:
- Osteosarcoma and Ewing sarcoma are the most common pediatric bone cancers, comprising ~6% of childhood malignancies.
- Advances in chemotherapy and limb-sparing surgery have significantly improved survival rates for these rare tumors.
Purpose of the Study:
- To review current treatment trends for pediatric osteosarcoma and Ewing sarcoma.
- To discuss available reconstructive surgical options.
- To evaluate methods and results for assessing long-term patient outcomes, including function and quality of life.
Main Methods:
- Literature review of current treatment modalities for pediatric bone sarcomas.
- Analysis of reconstructive techniques for limb preservation.
- Examination of functional and quality-of-life assessment tools for long-term survivors.
Main Results:
- Significant improvements in medical treatments have led to increased long-term survival.
- Enhanced reconstructive techniques preserve limb function in pediatric patients.
- Developing and utilizing child-specific measures for functional and quality-of-life outcomes.
Conclusions:
- This review provides an overview of current treatment options for pediatric malignant bone tumors.
- It highlights long-term complications and evaluation methods relevant to pediatric oncologists and orthopedic surgeons.
- Understanding outcomes is crucial for managing long-term survivors of childhood bone cancers.
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