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Related Concept Videos

Modified-Release Drug Delivery Systems: Rate-Programmed II01:19

Modified-Release Drug Delivery Systems: Rate-Programmed II

Rate-programmed drug delivery systems release drugs in a controlled manner to maintain therapeutic levels. Three main designs include reservoir, matrix, and hybrid systems.Reservoir systems consist of a drug core enclosed within a membrane that controls drug release. In non-swelling reservoir systems, polymers like ethyl cellulose or polymethacrylates are used. These do not hydrate in aqueous media and control release through membrane thickness, porosity, or insolubility. This type includes...
Site-Targeted Drug Delivery Systems: Polymeric Carriers01:24

Site-Targeted Drug Delivery Systems: Polymeric Carriers

Polymeric carriers enhance targeted drug delivery by increasing efficacy while minimizing off-target effects. These carriers comprise a biodegradable polymeric backbone integrated with functional elements that enable targeting, improve physicochemical properties, and regulate drug release.Targeting MechanismsThe targeting ability of polymeric carriers is mediated by a homing device, which is a molecular recognition component designed to selectively bind to specific tissues or cells. Monoclonal...
Modified-Release Drug Delivery Systems: Classification01:23

Modified-Release Drug Delivery Systems: Classification

Modified-release drug delivery systems improve drug efficacy and minimize side effects by controlling the rate and location of drug release. These systems fall into three categories: rate-programmed, stimuli-activated, and site-targeted.Rate-programmed systems release drugs at a predetermined rate, maintaining consistent therapeutic levels and reducing fluctuations that could lead to toxicity or subtherapeutic effects. These systems use polymeric matrices, reservoir-based designs, or osmotic...
Modified-Release Drug Delivery Systems: Stimuli-Activated01:30

Modified-Release Drug Delivery Systems: Stimuli-Activated

Stimuli-activated drug delivery systems are designed to release drugs in response to specific physical, chemical, or biological stimuli. These systems often utilize hydrogels—three-dimensional, hydrophilic polymer networks capable of swelling in aqueous environments and retaining significant fluid volumes. Upon exposure to particular stimuli, these hydrogels undergo structural transitions that allow the embedded drug to be released. Due to this adaptive behavior, such systems are also called...
Modified-Release Drug Delivery Systems: Rate-Programmed I01:22

Modified-Release Drug Delivery Systems: Rate-Programmed I

Rate-programmed drug delivery systems (DDS) are designed to release drugs at specific, controlled rates to maintain consistent therapeutic levels. These systems are categorized based on their release mechanisms, including dissolution-controlled DDS, diffusion-controlled DDS, and combined dissolution-diffusion-controlled DDS.In dissolution-controlled DDS, the release rate depends on the slow dissolution of the drug itself or the surrounding matrix. Drugs with inherently slow dissolution rates,...
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Modified-Release Drug Delivery Systems: Influencing Factors

Modified-release drug delivery systems are designed to optimize the therapeutic effect of drugs by minimizing side effects, reducing the dosage required, and controlling drug release to align with pharmacokinetic and pharmacodynamic needs. The system depends on two key factors: the drug's release from the formulation and its movement through the body to the target site. Unlike conventional dosage forms, where absorption is the limiting step, the rate of drug release is the key determinant in...

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Nanosponge Tunability in Size and Crosslinking Density
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Tunable drug loading and release from polypeptide multilayer nanofilms.

Bingbing Jiang1, Bingyun Li

  • 1Biomaterials, Bioengineering and Nanotechnology Laboratory, Department of Orthopaedics, School of Medicine, West Virginia University, Morgantown, WV, USA.

International Journal of Nanomedicine
|May 8, 2009
PubMed
Summary

Biodegradable polypeptide multilayer nanofilms can load and release drugs in a controlled manner. These novel drug delivery systems show promise for preventing infections associated with biomedical devices.

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Area of Science:

  • Biomaterials Science
  • Nanotechnology
  • Drug Delivery Systems

Background:

  • Biomedical device-associated infections are a significant clinical problem.
  • Existing treatments often face challenges with efficacy and resistance.
  • Novel drug delivery systems are needed to combat these infections.

Purpose of the Study:

  • To develop and characterize polypeptide multilayer nanofilms for drug delivery.
  • To investigate the loading and release mechanisms of charged drug molecules within these nanofilms.
  • To evaluate the antibacterial efficacy of drug-loaded nanofilms.

Main Methods:

  • Electrostatic layer-by-layer self-assembly was used to create polypeptide multilayer nanofilms.
  • Various charged drug molecules (cefazolin, gentamicin, methylene blue) were loaded into the nanofilms.
  • Drug loading, release kinetics, and antibacterial properties were analyzed under different conditions (pH, film layers, incubation time, heat treatment).

Main Results:

  • Polypeptide multilayer nanofilms successfully loaded small charged drug molecules.
  • Drug loading and release were found to be pH-dependent and controllable.
  • Antibiotic-loaded nanofilms demonstrated controllable antibacterial activity against Staphylococcus aureus.
  • The nanofilms are biodegradable and can load both positively and negatively charged drugs.

Conclusions:

  • Developed biodegradable polypeptide multilayer nanofilms offer tunable drug loading and release.
  • These nanofilms show potential as effective drug delivery systems for biomedical devices.
  • They can help prevent biomedical device-associated infections in patients.