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Proteomics01:33

Proteomics

A proteome is the entire set of proteins that a cell type produces. We can study proteomes using the knowledge of genomes because genes code for mRNAs, and the mRNAs encode proteins. Although mRNA analysis is a step in the right direction, not all mRNAs are translated into proteins.
Proteomics is the study of proteomes' function. It involves the large-scale systematic study of the proteome to denote the protein complement expressed by a genome. Scientist Mark Wilkins coined the term proteomics...
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Microbes and Other Elemental Cycles

Microbial activity plays a pivotal role in the biogeochemical cycling of iron and manganese, especially at the redox gradients characteristic of stratified aquatic environments. These cycles are driven by microbial transformations between oxidized and reduced forms of the metals, allowing organisms to exploit them for metabolic energy and structural purposes.Iron Cycling Across Redox GradientsIn neutral, oxygen-rich surface waters, iron is predominantly found in its oxidized, insoluble ferric...
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Properties of Organometallic Compounds

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Extraction: Advanced Methods00:56

Extraction: Advanced Methods

Metal ions can be separated from one another by complexation with organic ligands–the chelating agent– to form uncharged chelates. Here, the chelating agent must contain hydrophobic groups and behave as a weak acid, losing a proton to bind with the metal. Since most organic ligands used in this process are insoluble or undergo oxidation in the aqueous phase, the chelating agent is initially added to the organic phase and extracted into the aqueous phase. The metal-ligand complex is formed in...
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Genomics

Genomics is the science of genomes: it is the study of all the genetic material of an organism. In humans, the genome consists of information carried in 23 pairs of chromosomes in the nucleus, as well as mitochondrial DNA. In genomics, both coding and non-coding DNA is sequenced and analyzed. Genomics allows a better understanding of all living things, their evolution, and their diversity. It has a myriad of uses: for example, to build phylogenetic trees, to improve productivity and...
Microbial Corrosion01:24

Microbial Corrosion

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Standards for Quantitative Metalloproteomic Analysis Using Size Exclusion ICP-MS
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Standards for Quantitative Metalloproteomic Analysis Using Size Exclusion ICP-MS

Published on: April 13, 2016

Metallomics: the concept and methodology.

Sandra Mounicou1, Joanna Szpunar, Ryszard Lobinski

  • 1Laboratoire de Chimie Analytique Bio-inorganique et Environnement, CNRS UMR 5254, Hélioparc, 2, av. Pr. Angot, F-64053, France.

Chemical Society Reviews
|May 8, 2009
PubMed
Summary
This summary is machine-generated.

Metallomics explores metal roles in life. This review highlights analytical methods, like hyphenated ICP-MS, for studying metal interactions with proteins and metabolites in vivo.

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Area of Science:

  • Metallomics
  • Analytical Chemistry
  • Biochemistry

Background:

  • Metallomics investigates metal-dependent biological processes at a molecular level.
  • Understanding metal ion interactions with biological molecules is crucial for deciphering life processes.
  • The review focuses on the interplay between metal ions and the genome, proteome, and metabolome.

Purpose of the Study:

  • To critically review the concept of metallomics.
  • To discuss analytical techniques for probing metal ion interactions with biological systems.
  • To highlight the role of bioinformatics and molecular biology in metallomics.

Main Methods:

  • Focus on hyphenated techniques combining separation methods (e.g., electrophoresis, chromatography) with mass spectrometry (ICP-MS, ESI-MS, MALDI-MS).
  • In vivo screening of native metal-protein and metal-metabolite complexes.
  • Utilizing bioinformatics for predicting metal-binding sites in proteins.
  • Employing molecular biology for detecting metal-dependent genes, proteins, and metabolites.

Main Results:

  • Detailed discussion of advanced analytical techniques for metallomics research.
  • Emphasis on the capability of hyphenated techniques to analyze native metal complexes in vivo.
  • Demonstration of the synergistic role of analytical chemistry, bioinformatics, and molecular biology.

Conclusions:

  • Metallomics is a rapidly advancing field essential for understanding metal-related biological functions.
  • Hyphenated analytical techniques are powerful tools for in vivo metallomic studies.
  • Integrated approaches involving bioinformatics and molecular biology are key to comprehensive metallomic analysis.