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Association between C-reactive protein and coronary calcium score in coronary artery disease
A Hosseinsabet1, A Mohebbi, A Almasi
1Department of Cardiology, Shaheed Rajaei Cardiovascular Center, Iran University of Medical Sciences, Tehran, Iran. ali_hosseinsabet@yahoo.com
Insights
High-sensitivity C-reactive protein (hs-CRP) did not correlate with coronary artery calcium score (CCS). These markers likely provide distinct cardiovascular risk information, with hs-CRP potentially reflecting acute events rather than atherosclerotic burden.
Area of Science:
- Cardiology
- Biomarkers
- Inflammation
Background:
- High-sensitivity C-reactive protein (hs-CRP) and coronary artery calcium score (CCS) are established cardiovascular risk markers.
- The relationship between hs-CRP, atherosclerotic burden, and acute coronary events remains unclear.
Purpose of the Study:
- To investigate the association between hs-CRP and CCS.
- To determine if hs-CRP reflects atherosclerotic burden or predicts acute coronary events.
Main Methods:
- Cross-sectional study of 143 patients undergoing coronary artery bypass grafting (CABG).
- Analysis of hs-CRP levels and CCS.
- Bivariant and multivariant statistical analyses were performed.
Main Results:
- No significant association was found between hs-CRP and CCS in the overall patient group.
- In patients not using statins, a significant positive association was observed in bivariant analysis (p = 0.001), but a significant negative association in multivariant analysis (p = 0.008).
Conclusions:
- hs-CRP is not correlated with CCS, suggesting distinct pathophysiological processes.
- hs-CRP may provide information on acute coronary events rather than established atherosclerotic burden.
- hs-CRP and CCS likely offer complementary, distinct insights into cardiovascular risk assessment.
Background:
Both high-sensitivity C-reactive protein (hs- CRP) and spiral computed tomography coronary artery calcium score (CCS) are valid markers of cardiovascular risk. It is unknown whether hs-CRP is a marker of atherosclerotic burden or if it reflects a process leading to acute coronary events.
Methods And Results:
We studied the association between hs- CRP and CCS in 143 patients who were candidates for coronary artery bypass grafting (CABG). In our cross-sectional study, we found no significant association between hs-CRP and the CCS in bivariant (p = 0.162) and multivariant (p = 0.062) analyses. However, in patients who did not use statins, this association was significant and positive in the bivariant analysis (p = 0.001), but in the multivariant analysis it was negative and significant (p = 0.008).
Conclusion:
High-sensitivity CRP was not correlated with CCS. The relationship between CRP and clinical events might not be related to atherosclerotic burden. Measures of inflammation, such as hs-CRP, and indices of atherosclerosis, such as CCS, are likely to provide distinct information regarding cardiovascular risk.
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