Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Brain Abscess l: Introduction

Brain Abscess l: Introduction

A brain abscess is a focal, intracerebral infection characterized by a localized collection of pus within the brain parenchyma, resulting from microbial invasion and the body’s inflammatory response. It progresses through stages: early and late cerebritis, followed by early and late capsule formation, reflecting tissue destruction, immune response, and eventual encapsulation.Etiology and PathogenesisCausative organisms vary with source and host factors, often involving polymicrobial infections,...

Cryptococcal Meningitis

Cryptococcal Meningitis

Cryptococcal meningitis is a life-threatening opportunistic infection predominantly associated with HIV/AIDS, accounting for over 100,000 deaths annually worldwide. However, it also affects individuals with other forms of immunosuppression, including those undergoing immunosuppressive therapy, organ transplant recipients, patients with innate immunodeficiencies, and individuals with hematological disorders. The infection is caused mainly by Cryptococcus neoformans and Cryptococcus gattii,...

Viral Meningitis

Viral Meningitis

Viral meningitis is the most common form of meningitis and is often referred to as aseptic meningitis to indicate the absence of bacterial involvement. It is generally milder than bacterial meningitis, with symptoms including fever, headache, stiff neck, drowsiness, nausea, photophobia, and vomiting. Rarely, more severe manifestations or death may occur. Common causative agents include enteroviruses, particularly coxsackie A and B viruses and echoviruses, all members of the Enterovirus genus...

Local Anesthetics: Clinical Application as Epidural Anesthesia

Local Anesthetics: Clinical Application as Epidural Anesthesia

Epidural anesthetics are administered in the fat-filled epidural space, the outermost part of the spinal canal. This technique is commonly employed for pain management and anesthesia during lower abdomen and pelvis surgeries or labor and delivery.
Since epidural anesthetics can be infused through an epidural catheter, all types of drugs, including short-acting ones, can be administered. Chloroprocaine and lidocaine are examples of short and long-duration anesthetics, respectively. Bupivacaine...

Bacterial Meningitis I: Introduction

Bacterial Meningitis I: Introduction

Bacterial meningitis is a severe, life-threatening inflammation of the meninges, particularly the pia mater and arachnoid mater, affecting the subarachnoid space, ventricles, and cerebrospinal fluid (CSF). If untreated, it can lead to significant neurological complications or death.Causative AgentsCommon pathogens vary with age and immune status. In adults, major organisms include Streptococcus pneumoniae, Neisseria meningitidis, and Haemophilus influenzae. Streptococcus agalactiae (group B...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Targeted amplification and MinION nanopore sequencing of key azole and echinocandin resistance determinants of clinically relevant Candida spp. from blood culture bottles.

Letters in applied microbiology·2021

Same author

Clinical evaluation of serological IgG antibody response on the Abbott Architect for established SARS-CoV-2 infection.

Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases·2020

Same author

Culture-confirmed cryptococcal meningitis not detected by Cryptococcus PCR on the Biofire meningitis/encephalitis panel<sup>®</sup>.

Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases·2018

Same author

Repurposing Zidovudine in combination with Tigecycline for treating carbapenem-resistant Enterobacteriaceae infections.

European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology·2017

Same author

Rapidly growing mycobacteria in Singapore, 2006-2011.

Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases·2015

Same author

The emergence of community-onset Clostridium difficile infection in a tertiary hospital in Singapore: a cause for concern.

International journal of antimicrobial agents·2013

Search research articles

Related Experiment Video

Updated: Jun 23, 2026

A Retrospective Study on Endoscopic Surgery for the Treatment of Paravertebral Abscess in Spinal Tuberculosis Patients

A Retrospective Study on Endoscopic Surgery for the Treatment of Paravertebral Abscess in Spinal Tuberculosis Patients

Published on: October 25, 2024

Aspergillus vertebral osteomyelitis and epidural abscess.

C W Tew¹, F C Han, R Jureen

¹Department of General Medicine, Alexandra Hospital, 378 Alexandra Road, Singapore. tewcheewee@hotmail.com

Singapore Medical Journal

|May 8, 2009

Summary

This case report details the first instance of Aspergillus vertebral osteomyelitis and epidural abscess in Singapore. Despite treatment, the aggressive fungal infection led to fatal multiorgan failure, highlighting the need for rapid diagnosis and intervention.

More Related Videos

Diagnosis and Surgical Treatment of Human Brucellar Spondylodiscitis

Diagnosis and Surgical Treatment of Human Brucellar Spondylodiscitis

Published on: May 23, 2021

Related Experiment Videos

Last Updated: Jun 23, 2026

A Retrospective Study on Endoscopic Surgery for the Treatment of Paravertebral Abscess in Spinal Tuberculosis Patients

A Retrospective Study on Endoscopic Surgery for the Treatment of Paravertebral Abscess in Spinal Tuberculosis Patients

Published on: October 25, 2024

Diagnosis and Surgical Treatment of Human Brucellar Spondylodiscitis

Diagnosis and Surgical Treatment of Human Brucellar Spondylodiscitis

Published on: May 23, 2021

Area of Science:

Medical Mycology
Infectious Diseases
Neurosurgery

Background:

Vertebral osteomyelitis and epidural abscesses are serious spinal infections.
Aspergillus species can cause invasive infections, particularly in immunocompromised individuals.
Post-tuberculous bronchiectasis may predispose patients to opportunistic infections.

Observation:

A 50-year-old man with a history of post-tuberculous bronchiectasis presented with Aspergillus vertebral osteomyelitis and epidural abscess.
Clinical manifestations included acute urinary retention and flaccid paraplegia.
The patient received surgical debridement and voriconazole treatment.

Findings:

Despite aggressive management, the patient experienced rapid disease progression.
Multiorgan failure developed within two weeks of presentation.
The fungal infection proved fatal, underscoring its aggressive nature.

Implications:

This case highlights the critical importance of early diagnosis for invasive Aspergillus infections of the spine.
Prompt initiation of appropriate antifungal therapy and surgical intervention is crucial.
Improved outcomes for this rare and aggressive condition depend on timely and effective management.