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Related Experiment Video

Updated: Jun 23, 2026

Printing Thermoresponsive Reverse Molds for the Creation of Patterned Two-component Hydrogels for 3D Cell Culture
10:49

Printing Thermoresponsive Reverse Molds for the Creation of Patterned Two-component Hydrogels for 3D Cell Culture

Published on: July 10, 2013

Shear-reversibly crosslinked alginate hydrogels for tissue engineering.

Honghyun Park1, Sun-Woong Kang, Byung-Soo Kim

  • 1Department of Bioengineering, College of Engineering, Hanyang University, Seoul 133-791, Republic of Korea.

Macromolecular Bioscience
|May 8, 2009
PubMed
Summary

Injectable hydrogels for tissue engineering were created using combined cell and ionic crosslinking. These shear-reversible alginate hydrogels effectively supported cartilage tissue formation in vivo.

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Last Updated: Jun 23, 2026

Printing Thermoresponsive Reverse Molds for the Creation of Patterned Two-component Hydrogels for 3D Cell Culture
10:49

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Published on: July 10, 2013

Core/shell Printing Scaffolds For Tissue Engineering Of Tubular Structures
05:52

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Synthesis of Thermogelling Poly(N-isopropylacrylamide)-graft-chondroitin Sulfate Composites with Alginate Microparticles for Tissue Engineering
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Synthesis of Thermogelling Poly(N-isopropylacrylamide)-graft-chondroitin Sulfate Composites with Alginate Microparticles for Tissue Engineering

Published on: October 26, 2016

Area of Science:

  • Biomaterials Science
  • Tissue Engineering
  • Regenerative Medicine

Background:

  • Injectable delivery vehicles are crucial for minimally invasive tissue engineering.
  • Shear-reversible hydrogels offer potential due to their ability to flow under stress and recover gel structure post-injection.

Purpose of the Study:

  • To develop injectable and shear-reversible alginate hydrogels using a combination crosslinking approach.
  • To investigate the impact of cell and calcium ion concentrations on hydrogel properties and gelation behavior.
  • To evaluate the efficacy of these hydrogels for in vivo cartilage tissue engineering.

Main Methods:

  • Preparation of alginate hydrogels via combined cell-crosslinking and ionic crosslinking.
  • Characterization of hydrogel physical properties and gelation dynamics.
  • Assessment of in vivo cartilage tissue formation using the developed hydrogels.

Main Results:

  • Injectable and shear-reversible alginate hydrogels were successfully prepared.
  • Calcium ions reduced the required cell concentration without compromising shear reversibility.
  • Hydrogel properties were tunable by adjusting cell and calcium ion concentrations.
  • Combination crosslinked hydrogels demonstrated effectiveness in engineering cartilage tissues in vivo.

Conclusions:

  • Combination crosslinking of alginate hydrogels provides a versatile method for creating injectable, shear-reversible systems.
  • This approach allows for controlled delivery of cells and therapeutics for minimally invasive regenerative therapies.
  • The developed hydrogels show significant promise for applications in tissue engineering, particularly for cartilage repair.