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Updated: May 5, 2026

Isolation of Double Negative αβ T Cells from the Kidney
Published on: May 16, 2014
New roles revealed for T cells and DCs in glomerulonephritis
Alfred H J Kim1, Mary A Markiewicz, Andrey S Shaw
1Department of Internal Medicine, Washington University School of Medicine, St. Louis, Missouri 63110, USA.
Abstract:
Little is known about the potential role of T cells in the inflammatory renal disease glomerulonephritis (GN). GN has been historically viewed as a product of immune complex-mediated complement activation, and the presence of autoantibodies made identifying T cell-specific effector contributions difficult to elucidate. In this issue of the JCI, Heymann et al. generate what they believe to be a novel, transgenic murine model of GN, demonstrating a direct role for CD8+ T cells, activated CD4+ T cells, and DCs in the pathogenesis of GN (see the related article beginning on page 1286).
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