Related Experiment Video

Updated: Jun 23, 2026

Enhancing the Development and Growth of Infant Cerebral Palsy Rats Using Selective Spinal Manipulations
05:04

Enhancing the Development and Growth of Infant Cerebral Palsy Rats Using Selective Spinal Manipulations

Published on: February 2, 2024

Dantrolene: new indication. Cerebral palsy in children: uncertain clinical benefit

    Prescrire International
    |May 9, 2009
    PubMed

    Insights

    Dantrolene

    Area of Science:

    • Pediatric pharmacology
    • Hepatology

    Background:

    • Limited data exists on dantrolene's effectiveness in children.
    • Adverse effects, particularly liver toxicity, are not well-documented in pediatric populations.

    Purpose of the Study:

    • To investigate the symptomatic efficacy of dantrolene in pediatric patients.
    • To characterize the adverse effects profile of dantrolene in children, with a focus on hepatotoxicity.

    Main Methods:

    • Systematic review of existing literature.
    • Analysis of case reports and clinical trials involving pediatric dantrolene use.

    Main Results:

    • Symptomatic efficacy data for dantrolene in children is scarce.
    • Hepatotoxicity is a noted concern, though detailed incidence and severity data are limited.

    Conclusions:

    • Further research is needed to establish dantrolene's efficacy and safety in pediatric populations.
    • Close monitoring for liver function is crucial when administering dantrolene to children.

    More Related Videos

    Repeated Transcranial Magnetic Stimulation Combined with Action Observation Training in Children with Spastic Cerebral Palsy07:20

    Repeated Transcranial Magnetic Stimulation Combined with Action Observation Training in Children with Spastic Cerebral Palsy

    Published on: August 9, 2024

    Abdominal Massage to Improve Motor Dysfunction in Rats with Cerebral Palsy08:24

    Abdominal Massage to Improve Motor Dysfunction in Rats with Cerebral Palsy

    Published on: August 11, 2023

    Related Concept Videos

    Directly Acting Muscle Relaxants: Dantrolene and Botulinum Toxin01:26

    Directly Acting Muscle Relaxants: Dantrolene and Botulinum Toxin

    Directly acting muscle relaxants like dantrolene and botulinum toxin (BoNT) have distinct mechanisms and applications. Dantrolene, a hydantoin derivative, acts on the ryanodine receptor (RYR1) in skeletal muscle cells. RYR1 are calcium channels present at the sarcoplasmic reticulum membrane. In response to excitation, they release calcium ions from the sarcoplasmic reticulum to the cytosol. Calcium promotes actin-myosin-mediated contraction of muscles.
    The binding of dantrolene to the RYR1...
    Skeletal Muscle Relaxants: Therapeutic Uses01:31

    Skeletal Muscle Relaxants: Therapeutic Uses

    Skeletal muscle relaxants are used to relax muscle tone and alleviate painful muscle contractions. However, the choice of skeletal muscle relaxants depends on the duration of the surgical procedure in order to minimize potential side effects. Skeletal muscle relaxants like neuromuscular blocking agents [NMBAs] are commonly employed as adjuvants alongside general anesthetics in clinical settings. NMBAs are also used to maintain controlled ventilation during surgery of the larynx or pharynx as...
    Skeletal Muscle Relaxants: Adverse Effects01:21

    Skeletal Muscle Relaxants: Adverse Effects

    Skeletal muscle relaxants are widely used for muscle paralysis and relieving pain following any muscle injury or stiffness. However, depending on the drug type, they can have adverse effects that range from mild to severe. Usually, nondepolarizing neuromuscular blockers have minimal side effects. For example, drugs like d-tubocurarine, cisatracurium, and rocuronium cause hypotension, whereas drugs like baclofen, when stopped abruptly, can lead to the recurrence of spastic conditions.
    Unlike...
    Classification of Skeletal Muscle Relaxants01:28

    Classification of Skeletal Muscle Relaxants

    Skeletal muscle relaxants are a group of drugs that can reduce muscle stiffness and induce temporary paralysis to relieve pain. These agents can act centrally to reduce muscle tone or spasms in painful conditions such as multiple sclerosis (MS), amyotrophic lateral sclerosis (ALS), or spinal injuries; they are called antispasmodics or spasmolytics.
    Peripherally acting skeletal muscle relaxants interfere with the neurotransmission at the neuromuscular end plate to induce paralysis during...
    Parkinson's Disease: Treatment01:24

    Parkinson's Disease: Treatment

    Neurodegenerative disorders, such as Parkinson's Disease (PD), involve the gradual and irreversible destruction of neurons in particular brain areas. These disorders exhibit standard features like proteinopathies, selective vulnerability of some neurons, and an interaction of intrinsic properties, genetics, and environmental influences in neural injury.
    Parkinson's Disease is primarily a result of the loss of dopaminergic neurons in the substantia nigra pars compacta. The cornerstone of its...
    Alterations in Muscle Tone ll01:12

    Alterations in Muscle Tone ll

    Alterations in muscle tone are common manifestations of neurological disorders and reflect dysfunction within different nervous system regions. Spasticity, paratonia, and dystonia represent distinct forms of hypertonia, each with unique mechanisms, clinical features, and diagnostic importance.CharacteristicsSpasticity happens from upper motor neuron lesions and is characterized by velocity-dependent resistance to passive movement. Clinical features include:Exaggerated deep tendon reflexesClonus...