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Related Experiment Video

Updated: Jun 23, 2026

Acupuncture Treatment in a Mouse Model of Chronic Hypoxia-Induced Cognitive Dysfunction
03:26

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Published on: December 8, 2023

Ketamine attenuates post-operative cognitive dysfunction after cardiac surgery.

J A Hudetz1, Z Iqbal, S D Gandhi

  • 1Department of Anesthesiology, Clement J. Zablocki Veterans Administration Medical Center, Milwaukee, WI. judith.hudetz@va.gov

Acta Anaesthesiologica Scandinavica
|May 9, 2009
PubMed
Summary
This summary is machine-generated.

Ketamine reduced post-operative cognitive dysfunction (POCD) in cardiac surgery patients. This neuroprotective effect may stem from ketamine's anti-inflammatory properties, lowering C-reactive protein levels.

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Published on: June 2, 2015

Area of Science:

  • Anesthesiology
  • Neuroscience
  • Cardiology

Background:

  • Post-operative cognitive dysfunction (POCD) is a common complication following cardiac surgery.
  • Ketamine is known for neuroprotective effects against cerebral ischemia via anti-excitotoxic and anti-inflammatory pathways.

Purpose of the Study:

  • To investigate if ketamine can attenuate POCD in patients undergoing cardiac surgery.
  • To explore the potential anti-inflammatory mechanism behind ketamine's neuroprotective effects in this context.

Main Methods:

  • A randomized controlled trial involving cardiac surgery patients.
  • Patients received either an intravenous bolus of ketamine (0.5 mg/kg) or placebo during anesthetic induction.
  • Cognitive functions and serum C-reactive protein (CRP) levels were assessed pre- and post-surgery.

Main Results:

  • Fewer patients in the ketamine group experienced significant cognitive decline compared to the placebo group (7 vs. 21).
  • Cognitive performance differences between ketamine and placebo groups were statistically significant.
  • Post-operative CRP levels were significantly lower in the ketamine group, suggesting an anti-inflammatory effect.

Conclusions:

  • Ketamine administration effectively attenuates post-operative cognitive dysfunction one week after cardiac surgery.
  • The neuroprotective effect of ketamine in this setting appears to be linked to its anti-inflammatory action, as indicated by reduced CRP levels.