Related Experiment Video
Updated: Jun 23, 2026
Modifying Levels of Maternal Dietary Folic Acid or Choline to Study the Impact of Deficiencies on Offspring Health Outcomes
Published on: June 28, 2024
Relationships between low serum cobalamin concentrations and methlymalonic acidemia in cats
C G Ruaux1, J M Steiner, D A Williams
1Gastrointestinal Laboratory, College of Veterinary Medicine and Biomedical Sciences, Texas A&M University, College Station, TX, USA. craig.ruaux@oregonstate.edu
Background:
Serum cobalamin concentrations below reference range are a common consequence of gastrointestinal disease in cats. Serum cobalamin
Objectives:
To determine the prevalence of cobalamin deficiency, defined by elevated serum methylmalonic acid (MMA), in cats with serum cobalamin
Methods:
Retrospective, observational study. Serum cobalamin and folate were measured with automated assays. Serum MMA was determined by gas chromatography-mass spectrometry. Cobalamin deficiency was defined as serum MMA > 867 nmol/L. Sensitivity and specificity of serum cobalamin concentrations
Results:
There was a negative correlation between serum cobalamin and MMA concentrations (Spearman's r=-0.74, P < 0.0001). The prevalence of MMA >or= 867 nmol/L in cats with serum cobalamin
Conclusions And Clinical Importance:
Elevated MMA concentrations, suggesting cobalamin deficiency, are common in cats with serum cobalamin
