Physical characteristics of the menstrual cycle and premenstrual depressive symptoms

Little is known about the associations between premenstrual depressive symptoms and specific physical symptoms of the menstrual cycle. In a nonclinical sample of 183 female university students, six physical symptoms of the menstrual cycle (headaches, skin changes, gastrointestinal problems, breast changes, and coagulation and heaviness of menstrual bleeding) were tested for their associations with premenstrual depressive symptoms. The physical symptoms explained nearly 30% of the variance in depressive symptoms. Moreover, when the summed score for all six physical symptoms was used as a predictor of depressive symptoms, a strong linear effect and a moderate curvilinear effect were observed. These results could not be explained by response bias or by the presence of a small group of highly depressed individuals. This study emphasizes the need to consider physical symptoms of the menstrual cycle to better understand premenstrual depressive symptoms, and suggests that the contribution of the menstrual cycle to depressive symptoms in the general population is underrecognized.