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[Hyperglycerolemia, a pseudo-hypertriglyceridemia: a case report]
F Fabiani Romero1, J A Bermúdez de la Vega, C González Martin
1Departamento de Bioquímica Clínica, Unidad de Riesgo Cardiovascular, Hospital Virgen Macarena, Sevilla, España. ffabiani@us.es
Anales De Pediatria (Barcelona, Spain : 2003)
|May 9, 2009
Summary
Elevated serum triglycerides are a risk factor for heart disease. A child
Area of Science:
- Clinical Chemistry
- Biochemistry
- Cardiovascular Disease Risk Factors
Background:
- National Cholesterol Education Program guidelines identify elevated serum triglycerides as an independent risk factor for coronary heart disease.
- Routine enzymatic methods for triglyceride measurement often do not use a glycerol blank, measuring both glycerol and triglycerides.
- Certain genetic conditions, like glycerol-kinase deficiency, can affect glycerol metabolism.
Observation:
- A case of pseudo-hypertriglyceridemia was observed in a pediatric patient.
- This condition presented as falsely elevated triglyceride levels.
Findings:
- The elevated triglyceride levels in this patient were attributed to hyperglycerolemia (excess glycerol in the blood).
- This highlights a potential diagnostic challenge in triglyceride measurement.
Implications:
- Accurate triglyceride measurement is crucial for cardiovascular risk assessment.
- Consideration of hyperglycerolemia is important in diagnosing pseudo-hypertriglyceridemia, especially in patients with potential glycerol metabolism disorders.
- This case underscores the need for careful interpretation of lipid profiles and potential method-dependent artifacts in clinical laboratories.
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