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Related Concept Videos

Hyperglycemia01:29

Hyperglycemia

Hyperglycemia is an abnormally high blood glucose level. It is diagnosed by fasting glucose ≥126 mg/dL, 2-hour oral glucose tolerance test (or OGTT) ≥200 mg/dL, random glucose ≥200 mg/dL with symptoms, or HbA1c ≥6.5%. However, HbA1c results may be unreliable in certain conditions, such as anemia or hemoglobinopathies, and the diagnosis should be confirmed unless classic symptoms are present. Postprandial hyperglycemia is typically considered significant when glucose levels exceed 180 mg/dL two...
Hypoglycemia and Glucagon01:15

Hypoglycemia and Glucagon

Without prolonged fasting, healthy individuals maintain blood glucose levels above 3.5 mM due to a well-adapted neuroendocrine counterregulatory system that effectively prevents acute hypoglycemia, a potentially life-threatening condition. The primary clinical scenarios for hypoglycemia encompass diabetes treatment, inappropriate production of endogenous insulin or insulin-like substances by tumors, and the use of glucose-lowering agents in non-diabetic individuals. Notably, hypoglycemia in the...
Blood Studies for Cardiovascular System III: Serum Lipid Profile01:25

Blood Studies for Cardiovascular System III: Serum Lipid Profile

Understanding serum lipids is crucial for maintaining cardiovascular health and preventing heart disease and stroke.
Serum lipids are fats and fatty substances in the blood and are crucial for various bodily functions, including energy storage, cellular structure, and hormone production. Serum lipids consist of cholesterol, triglycerides, and phospholipids.
Cholesterol is a soft, fat-like substance found in all body cells. It is crucial for producing hormones, vitamin D, and substances that aid...
Hyperosmolar Hyperglycemic State01:21

Hyperosmolar Hyperglycemic State

Hyperosmolar Hyperglycemic State, or HHS, is a serious and life-threatening complication of type 2 diabetes mellitus. It is characterized by three main features: severe hyperglycemia, profound dehydration, and elevated serum osmolality, all occurring without significant ketoacidosis.HHS typically develops in older adults or individuals with limited access to fluids. This may result from illness, cognitive impairment, or medications such as diuretics or corticosteroids. These factors reduce...
Hypoglycemia01:26

Hypoglycemia

Hypoglycemia is a blood glucose level below 70 mg/dL. It commonly occurs in individuals using insulin or insulin-secreting drugs, but may also arise in non-diabetic conditions. People with type 1 diabetes are at the highest risk because they depend on exogenous insulin. People with type 2 diabetes are also at risk, especially when treated with insulin or medications such as sulfonylureas, which increase insulin release regardless of blood glucose levels. It develops when insulin levels exceed...
Overview of Lipid Metabolism01:24

Overview of Lipid Metabolism

Lipid metabolism is a crucial process in the human body that involves the synthesis and degradation of lipids. This process is essential for energy production, cell membrane formation, and hormone production, among other functions.
Lipolysis: The Breakdown of Lipids:
Lipolysis is the process of breaking down lipids, particularly triglycerides, into glycerol and fatty acids. This process typically occurs in the adipose tissue and is triggered by various hormones, including glucagon and...

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Related Experiment Video

Updated: Jun 23, 2026

Assessing Whole-Body Lipid-Handling Capacity in Mice
07:57

Assessing Whole-Body Lipid-Handling Capacity in Mice

Published on: November 24, 2020

[Hyperglycerolemia, a pseudo-hypertriglyceridemia: a case report].

F Fabiani Romero1, J A Bermúdez de la Vega, C González Martin

  • 1Departamento de Bioquímica Clínica, Unidad de Riesgo Cardiovascular, Hospital Virgen Macarena, Sevilla, España. ffabiani@us.es

Anales De Pediatria (Barcelona, Spain : 2003)
|May 9, 2009
PubMed
Summary

Elevated serum triglycerides are a risk factor for heart disease. A child

Related Experiment Videos

Last Updated: Jun 23, 2026

Assessing Whole-Body Lipid-Handling Capacity in Mice
07:57

Assessing Whole-Body Lipid-Handling Capacity in Mice

Published on: November 24, 2020

Area of Science:

  • Clinical Chemistry
  • Biochemistry
  • Cardiovascular Disease Risk Factors

Background:

  • National Cholesterol Education Program guidelines identify elevated serum triglycerides as an independent risk factor for coronary heart disease.
  • Routine enzymatic methods for triglyceride measurement often do not use a glycerol blank, measuring both glycerol and triglycerides.
  • Certain genetic conditions, like glycerol-kinase deficiency, can affect glycerol metabolism.

Observation:

  • A case of pseudo-hypertriglyceridemia was observed in a pediatric patient.
  • This condition presented as falsely elevated triglyceride levels.

Findings:

  • The elevated triglyceride levels in this patient were attributed to hyperglycerolemia (excess glycerol in the blood).
  • This highlights a potential diagnostic challenge in triglyceride measurement.

Implications:

  • Accurate triglyceride measurement is crucial for cardiovascular risk assessment.
  • Consideration of hyperglycerolemia is important in diagnosing pseudo-hypertriglyceridemia, especially in patients with potential glycerol metabolism disorders.
  • This case underscores the need for careful interpretation of lipid profiles and potential method-dependent artifacts in clinical laboratories.