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Mesenchymal Stem Cells

Mesenchymal Stem Cells

Mesenchymal stem cells (MSCs) are adult stem cells that can differentiate into most connective tissue cell types, except for hematopoietic cells, depending upon the source of MSCs. For example, bone-marrow-derived MSCs (BM-MSCs) can differentiate into osteocytes, hepatocytes, and pancreatic and neuronal cells. MSCs can be isolated from various sources such as bone marrow, placenta, adipose tissue, teeth, and Wharton’s jelly, a gelatinous substance in the umbilical cord. The ease of their access...

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Related Experiment Video

Updated: Jun 23, 2026

Homing of Hematopoietic Cells to the Bone Marrow

Homing of Hematopoietic Cells to the Bone Marrow

Published on: March 18, 2009

Mesenchymal stem cell homing capacity.

Valeria Sordi¹

¹Beta Cell Biology Unit, Diabetes Research Institute, San Raffaele Scientific Institute, Milan, Italy.

Transplantation

|May 9, 2009

Summary

This summary is machine-generated.

Mesenchymal stem cells (MSCs) show promise for tissue repair due to their ability to migrate and engraft. Chemokines and their receptors likely control MSC homing to target tissues, influencing cell migration and therapy effectiveness.

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Last Updated: Jun 23, 2026

Homing of Hematopoietic Cells to the Bone Marrow

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Published on: March 18, 2009

Ultrasound-guided Intracardiac Injection of Human Mesenchymal Stem Cells to Increase Homing to the Intestine for Use in Murine Models of Experimental Inflammatory Bowel Diseases

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Isolation of CD146+ Resident Lung Mesenchymal Stromal Cells from Rat Lungs

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Published on: June 17, 2016

Area of Science:

Biomedical Science
Regenerative Medicine
Cell Biology

Background:

Mesenchymal stem cells (MSCs) are crucial for tissue regeneration and repair.
MSCs are readily sourced from bone marrow (BM) and possess differentiation and immunomodulatory capabilities.
Effective cell therapies depend on MSCs' ability to home and engraft into target tissues.

Purpose of the Study:

To investigate the mechanisms of Mesenchymal stem cells (MSCs) homing and migration.
To understand the role of chemokines and their receptors in MSC recruitment to tissues.
To elucidate the specific axes involved in Mesenchymal stem cells (MSCs) interaction with target cells, such as pancreatic islets.

Main Methods:

Review of existing literature on Mesenchymal stem cells (MSCs) homing and migration.
Analysis of the known roles of chemokines and chemokine receptors in cell trafficking.
Focus on specific chemokine axes like CXCR4-CXCL12 and CX3CR1-CX3CL1 in Mesenchymal stem cells (MSCs) biology.

Main Results:

Mesenchymal stem cells (MSCs) possess inherent homing capabilities to bone marrow and other organs.
Chemokines and their receptors are strongly implicated in controlling Mesenchymal stem cells (MSCs) migration and tissue recruitment.
The CXCR4-CXCL12 and CX3CR1-CX3CL1 pathways are identified as key mediators in the interaction between Mesenchymal stem cells (MSCs) and pancreatic islets.

Conclusions:

Mesenchymal stem cells (MSCs) homing mechanisms are critical for their therapeutic potential.
Chemokine signaling pathways are essential for directing Mesenchymal stem cells (MSCs) to target tissues.
Understanding these pathways, like CXCR4-CXCL12 and CX3CR1-CX3CL1, is vital for optimizing Mesenchymal stem cells (MSCs)-based therapies, particularly in contexts like pancreatic islet interactions.