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Updated: Jun 23, 2026

Human In Vitro Suppression as Screening Tool for the Recognition of an Early State of Immune Imbalance
Published on: July 22, 2011
[Immunosuppression - too strong or too weak?]
A Schneidewind1, M Fleck, B Salzberger
1Klinik für Innere Medizin I, Universitätsklinikum Regensburg, Franz-Josef-Strauss-Allee 11, 93051 Regensburg. arne.schneidewind@klinik.uni-r.de
Abstract:
A 52 year old patient with immunosuppressive therapy for ANCA-negative vasculitis presented with fever and paraparesis of the legs, laboratory findings displayed high inflammatory markers. The differential diagnosis comprised acute infection, an exacerbation of vasculitis or a drug reaction. Despite meticulous diagnostics, including FDG-PET, no definitive cause for the symptoms could be uncovered. Empirical antibiotic treatment in combination with high doses of glucocorticosteroids lead to prompt resolution of fever and inflammatory laboratory markers.
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