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Related Concept Videos

Immunodeficiency Diseases01:25

Immunodeficiency Diseases

Immunodeficiency disorders are conditions in which the immune system's ability to fight infectious disease and cancer is compromised or entirely absent. The immune system comprises a complex network of cells, tissues, and organs that work together to protect the body from potentially harmful invaders. When this system is deficient or not functioning properly, it leaves the body susceptible to infections, diseases, or other complications.
There are three main causes of immunodeficiency disorders...
Cell-mediated Immune Responses01:40

Cell-mediated Immune Responses

Overview
Humoral Immune Responses01:36

Humoral Immune Responses

Overview
Pulmonary Tuberculosis I01:29

Pulmonary Tuberculosis I

Tuberculosis, often called TB, is a contagious illness primarily caused by Mycobacterium tuberculosis. It mainly affects the lung parenchyma but can also impact other body parts.
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...
Tumor Immunotherapy01:27

Tumor Immunotherapy

Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
Drug toxicity: Idiosyncratic Reactions01:16

Drug toxicity: Idiosyncratic Reactions

Idiosyncratic drug reactions represent abnormal chemical responses that vary significantly among individuals, ranging from extreme sensitivity to low doses to insensitivity to high doses. These reactions often occur due to the drug's covalent binding with serum proteins, forming a foreign hapten that triggers an immunotoxicological response. The variability in drug reactions has a strong pharmacogenetic foundation, with genetic differences crucial in how individuals metabolize drugs. For...

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Updated: Jun 23, 2026

Human In Vitro Suppression as Screening Tool for the Recognition of an Early State of Immune Imbalance
14:01

Human In Vitro Suppression as Screening Tool for the Recognition of an Early State of Immune Imbalance

Published on: July 22, 2011

[Immunosuppression - too strong or too weak?].

A Schneidewind1, M Fleck, B Salzberger

  • 1Klinik für Innere Medizin I, Universitätsklinikum Regensburg, Franz-Josef-Strauss-Allee 11, 93051 Regensburg. arne.schneidewind@klinik.uni-r.de

Der Internist
|May 9, 2009
PubMed
Summary
This summary is machine-generated.

A patient with vasculitis experienced fever and leg weakness. Prompt treatment with antibiotics and steroids resolved symptoms, despite an unclear diagnosis after extensive testing.

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In Vitro and In Vivo Assessment of T, B and Myeloid Cells Suppressive Activity and Humoral Responses from Transplant Recipients

Published on: August 12, 2017

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Last Updated: Jun 23, 2026

Human In Vitro Suppression as Screening Tool for the Recognition of an Early State of Immune Imbalance
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Published on: July 22, 2011

Quantification of the Immunosuppressant Tacrolimus on Dried Blood Spots Using LC-MS/MS
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In Vitro and In Vivo Assessment of T, B and Myeloid Cells Suppressive Activity and Humoral Responses from Transplant Recipients

Published on: August 12, 2017

Area of Science:

  • Immunology
  • Neurology
  • Infectious Diseases

Background:

  • ANCA-negative vasculitis requires immunosuppressive therapy.
  • Fever and paraparesis indicate potential serious underlying conditions.

Observation:

  • A 52-year-old patient on immunosuppression presented with fever and leg weakness.
  • High inflammatory markers were noted, with differential diagnoses including infection, vasculitis exacerbation, or drug reaction.

Findings:

  • Despite thorough diagnostics like FDG-PET, the cause remained elusive.
  • Empirical treatment with antibiotics and high-dose glucocorticosteroids led to rapid symptom and inflammatory marker resolution.

Implications:

  • This case highlights the diagnostic challenges in immunosuppressed patients.
  • Prompt empirical treatment can be effective even without a definitive diagnosis.