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Updated: Jun 23, 2026

Simultaneous Photothrombosis and Fiber Photometry to Induce and Monitor Ischemic Stroke in Behaving Mice
Published on: November 14, 2025
[Some aspects of metabolic dysregulation in patients with ischemic stroke]
Abstract:
To study the mechanisms of formation of an endogenous intoxication syndrome in patients after ischemic stroke, the activity of platelet monoaminooxidase (MAO) and serum aminooxidase, concentration of middle-size molecules and parameters of functional albumin activity have been determined in 27 patients with illness duration 4-5 months and 16 healthy age- and sex-matched controls. The significant dysregulation of biogenic amine metabolism and total homeostasis was observed in patients compared to controls. There were a significant increase of MAO and concentration of middle-size molecules and a decrease of aminooxidase and functional albumin activity (p < 0.01). Such metabolic disturbances suggest a presence of endogenous intoxication. A possible mechanism of formation of an endogenous intoxication syndrome in ischemic stroke is discussed.
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