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Updated: Jun 23, 2026

Examining the Characteristics of Episodic Memory using Event-related Potentials in Patients with Alzheimer's Disease
Published on: August 30, 2011
[Electrophysiological changes in patients with early stages of Alzheimer's disease]
Kamila Krasodomska1, Wojciech Lubiński, Andrzej Potemkowski
1Katedra i Klinika Okulistyki Pomorskiej Akademii Medycznej w Szczecinie al. Powstańców Wlkp. 72, 70-111 Szczecin.
Purpose:
An evaluation of retinal and optic nerve bioelectrical function in patients with early stages of Alzheimer's disease.
Materials And Methods:
30 eyes of 15 patients in the early stage of Alzheimer's disease with normal eye fundus appearance were analysed. Electrophysiological tests of the retina and optic nerve (FVEP, PVEP, PERG, ERG) were performed according to ISCEV standards.
Results:
The dysfunction of the retina and optic nerve was observed. The most common abnormalities were noted in PVEP test (latency increase of P100-wave--36.7% eyes) and in PERG test (latency increase of P50-wave--33.3% eyes).
Conclusion:
In patients with early stage of Alzheimer's disease there is a dysfunction of the retina and optic nerve, which can be detected by electrophysiological tests, even in patients with normal eye fundus.
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