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Related Concept Videos

DNA Microarrays02:34

DNA Microarrays

Microarrays are high-throughput and relatively inexpensive assays that can be automated to analyze large quantities of data at a time. They are used in genome-wide studies to compare gene or protein expression under two varied conditions, such as healthy and diseased states. Microarrays consist of glass or silica slides on which probe molecules are covalently attached through surface functionalization. Most commonly, the slides are prepared through the chemisorption of silanes to silica...
Protein Glycosylation01:25

Protein Glycosylation

Glycosylation, the most common post-translational modification for proteins, serves diverse functions. Adding sugars to proteins makes the proteins more resistant to proteolytic digestion. Glycosylated proteins can act as markers and receptors to promote cell-cell adhesion. Additionally, they have many essential quality control functions in the cell, such as correct protein folding and facilitating transport of misfolded proteins to the cytosol, which can be degraded.
Glycosylation occurs in...
Overview of Carbohydrate Metabolism01:19

Overview of Carbohydrate Metabolism

Carbohydrate metabolism is a fundamental biochemical process that ensures a constant supply of energy to living cells. The most important carbohydrate is glucose, which can be broken down via glycolysis to enter into the Krebs cycle and eventually lead to the production of ATP through oxidative phosphorylation.
Glucose transport into cells is facilitated by a family of transport proteins called GLUT (Glucose Transporters). GLUT4 is the primary glucose transporter for insulin-stimulated glucose...
Glycocalyx and its Functions01:14

Glycocalyx and its Functions

The glycocalyx is a carbohydrate-rich, fuzzy-appearing layer on the outer surface of the cell membrane. It is highly hydrophilic, because of this it attracts large amounts of water to the cell's surface. This aids the cell's interaction with the watery environment and also helps it to obtain substances dissolved in the water. It is also important for cell identification, self/non-self determination, and embryonic development and is used in cell-to-cell attachments to form tissues.
Components of...
Carbohydrate Metabolism01:36

Carbohydrate Metabolism

Carbohydrates are polymers composed of molecules containing atoms of carbon, hydrogen and oxygen. One gram of carbohydrate can provide four kilo-calories of energy, which makes it the most efficient instant energy source.
Starch accounts for approximately 60% of the carbohydrates consumed by humans. Since amylase enzymes cannot function in the stomach's acidic environment, starch can only be digested in the mouth and small intestine. Simple sugars are found naturally in milk and fruits in the...
Carbohydrate Metabolism01:36

Carbohydrate Metabolism

Carbohydrates are polymers composed of molecules containing atoms of carbon, hydrogen and oxygen. One gram of carbohydrate can provide four kilo-calories of energy, which makes it the most efficient instant energy source.
Starch accounts for approximately 60% of the carbohydrates consumed by humans. Since amylase enzymes cannot function in the stomach's acidic environment, starch can only be digested in the mouth and small intestine. Simple sugars are found naturally in milk and fruits in the...

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Updated: Jun 23, 2026

Printed Glycan Array: A Sensitive Technique for the Analysis of the Repertoire of Circulating Anti-carbohydrate Antibodies in Small Animals
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Printed Glycan Array: A Sensitive Technique for the Analysis of the Repertoire of Circulating Anti-carbohydrate Antibodies in Small Animals

Published on: February 14, 2019

Carbohydrate microarrays: key developments in glycobiology.

Yan Liu1, Angelina S Palma, Ten Feizi

  • 1Glycosciences Laboratory, Division of Medicine, Imperial College London, Northwick Park and St. Mark's Campus, Harrow HA1 3UJ, Middlesex, UK.

Biological Chemistry
|May 12, 2009
PubMed
Summary

Carbohydrate microarrays are revolutionizing glycomics by enabling the study of carbohydrate-protein interactions. This technology is crucial for understanding biological processes, host-microbe interactions, and immune responses.

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Last Updated: Jun 23, 2026

Printed Glycan Array: A Sensitive Technique for the Analysis of the Repertoire of Circulating Anti-carbohydrate Antibodies in Small Animals
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Microarray Polymer Profiling (MAPP) for High-Throughput Glycan Analysis
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Published on: May 4, 2012

Area of Science:

  • Glycomics
  • Biomedical Sciences
  • Carbohydrate Chemistry

Background:

  • Carbohydrate chains on biomolecules are vital for biological and medical processes.
  • Understanding carbohydrate-protein interactions is a key priority in biomedical research.

Purpose of the Study:

  • To review the principles of carbohydrate microarray platforms.
  • To highlight platforms that have yielded significant biological insights.

Main Methods:

  • Review of carbohydrate microarray technology platforms introduced since 2002.
  • Focus on platforms that have moved beyond proof-of-concept.

Main Results:

  • Carbohydrate microarrays are a transformative tool in glycomics.
  • These platforms are essential for elucidating specific carbohydrate-protein interactions.

Conclusions:

  • Carbohydrate microarray technology is advancing the study of biological recognition events.
  • This technology is critical for understanding diverse biological and medical phenomena, including immunity and host-pathogen interactions.