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Clinical study of the relationship between inflammatory bowel diseases and colorectal neoplasms
1Department of Gastroenterology, Shanghai Public Health Clinical Centre affiliated to Fudan University, Shanghai, China.
Objective:
To investigate the incidence of colorectal cancer in inflammatory bowel disease (IBD) patients and its risk factors.
Methods:
Data on 513 patients in the last 10 years from Ruijin Hospital were collected. Their medical histories were put in database and analyzed including their socio-demographic features, pathogenetic conditions, diagnostic methods, possible related risk factors, treatment and outcome.
Results:
Among the 513 were 242 with ulcerative colitis (UC), among whom four patients developed cancers and four had precancerous lesions. None of the 271 CD patients developed cancer. The incidence of both cancer and precancerosis in the UC patients was 1.65%. Through multifactorial logistic regression analysis, loss of weight, other disease complications and frequent relapses were proved to be the most probable risk factors.
Conclusion:
The incidence of IBD has kept on rising in recent years. Clinically, UC patients have more probability of developing colorectal cancer than CD patients. The main risk factors of developing colorectal cancer in UC patients are frequent relapses, weight loss and other complications.
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