Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Continuous Renal Replacement Therapy01:30

Continuous Renal Replacement Therapy

Continuous Renal Replacement Therapy, also known as CRRT, is a procedural treatment for acute kidney injury (AKI) that gradually removes uremic toxins and fluids while maintaining acid-base balance and stabilizing electrolytes. It is particularly useful for hemodynamically unstable patients. Unlike intermittent hemodialysis, which is faster, CRRT provides a gentler approach over 24 hours, closely mimicking the function of natural kidneys. However, CRRT is not ideal for patients with...
Extracorporeal Removal of Drugs: Continuous Renal Replacement Therapy01:26

Extracorporeal Removal of Drugs: Continuous Renal Replacement Therapy

Continuous Renal Replacement Therapy (CRRT) is an essential intervention for patients experiencing severe kidney dysfunction. This therapy offers a continuous mechanism for removing fluids and toxins from the bloodstream, leveraging the patient’s blood pressure to facilitate filtration through a specialized filter. This method contrasts with intermittent dialysis, providing a gentler and more consistent removal of waste products and excess fluid, which is particularly beneficial in critically...
Acute Kidney Injury V: Interprofessional Care01:20

Acute Kidney Injury V: Interprofessional Care

Acute Kidney Injury (AKI) requires a collaborative healthcare approach to restore renal function and prevent complications. Essential management strategies involve monitoring fluid and electrolyte balance, adjusting medications, initiating dialysis when necessary, and providing nutritional support.Fluid and Electrolyte ManagementFluid Monitoring: Regularly monitoring body weight, central venous pressure, and urine output helps detect fluid imbalances early. Patient intake and output are...
Cardiac Catheterization I: Pre-Procedure Overview01:28

Cardiac Catheterization I: Pre-Procedure Overview

Cardiac catheterization is an invasive diagnostic technique used to identify and evaluate structural and functional diseases of the heart and major blood vessels. This technique diagnoses congenital heart disease, coronary artery disease, valvular heart disease, and coronary spasms and assesses ventricular function. It helps guide treatment decisions, including the need for revascularization procedures like percutaneous coronary intervention (PCI) or coronary artery bypass grafting (CABG) and...
Venous Thrombosis III: Interprofessional Care01:29

Venous Thrombosis III: Interprofessional Care

Venous thrombosis requires effective prevention and treatment strategies to improve patient outcomes and reduce potential complications.Prevention StrategiesHealthcare providers must prioritize preventing venous thromboembolism (VTE) for all adult patients upon admission. Interventions depend on bleeding and thrombosis risk, medical history, current medications, diagnoses, planned procedures, and patient preferences. Patients on bed rest should change positions every two hours and, if not...
Chronic Kidney Disease III: Interprofessional Care01:28

Chronic Kidney Disease III: Interprofessional Care

Chronic kidney disease (CKD) requires collaborative and comprehensive management. CKD progresses through stages and can lead to end-stage kidney disease (ESKD) if untreated. Interprofessional collaboration and patient education are crucial, enabling patients to manage their health and improve their quality of life.Diagnostic approach for chronic kidney diseaseThe diagnosis of CKD primarily focuses on the glomerular filtration rate (GFR), which assesses kidney function by measuring how well...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

LATAM-AKID registry: an international multicentre, observational study of acute kidney injury requiring dialysis in Latin America.

BMJ open·2026
Same author

Association of implementation of an EHR-based sepsis alert system with sepsis-associated acute kidney injury.

The American journal of emergency medicine·2026
Same author

COVID-19 and Interstitial Lung Disease.

Medicina (Kaunas, Lithuania)·2026
Same author

Association of platelet trajectory patterns with in-hospital mortality in critically ill adults with acute kidney injury receiving continuous renal replacement therapy.

BMC nephrology·2025
Same author

Change in platelet and leukocyte counts and hospital mortality in adults with acute kidney injury receiving continuous renal replacement therapy.

Scientific reports·2025
Same author

Epidemiology of sepsis-associated acute kidney injury in the ICU with contemporary consensus definitions.

Critical care (London, England)·2025
Same journal

Intracardiac Vascular Access for Hemodialysis Despite Associated Ascending Aortic Aneurysm.

Seminars in dialysis·2026
Same journal

Measures of Equivalent Hemodialysis Urea Clearance and Their Proposed Utility for Monitoring Adequacy.

Seminars in dialysis·2026
Same journal

Risk of Serious Adverse Events and Death With Low-Dose Methotrexate Versus Hydroxychloroquine in Adults Receiving Dialysis.

Seminars in dialysis·2026
Same journal

Severe Hematoma Following Initial Arteriovenous Fistula Puncture in a Hemodialysis Patient, Emphasizing Thoracic Outlet Syndrome: A Case Report.

Seminars in dialysis·2026
Same journal

Phosphate Kinetic Modeling in Patients Treated With Hemodialysis or Hemodiafiltration: A Prospective, Multicenter, Cross-Sectional Study.

Seminars in dialysis·2026
Same journal

Impact of Expanded Hemodialysis on Inflammation and Iron Metabolism in Chronic Hemodialysis Patients.

Seminars in dialysis·2026
See all related articles

Related Experiment Video

Updated: Jun 23, 2026

Use of a Hanging-weight System for Isolated Renal Artery Occlusion
07:54

Use of a Hanging-weight System for Isolated Renal Artery Occlusion

Published on: July 19, 2011

Anticoagulation for continuous renal replacement therapy.

Ashita J Tolwani1, Keith M Wille

  • 1Division of Nephrology, University of Alabama at Birmingham, AL 35294-0007, USA. atolwani@uab.edu

Seminars in Dialysis
|May 12, 2009
PubMed
Summary
This summary is machine-generated.

Anticoagulation is crucial for continuous renal replacement therapy (CRRT) in critically ill patients. While heparin is common, alternative methods like citrate anticoagulation offer safer options for managing acute kidney injury and hemodynamic instability.

Related Experiment Videos

Last Updated: Jun 23, 2026

Use of a Hanging-weight System for Isolated Renal Artery Occlusion
07:54

Use of a Hanging-weight System for Isolated Renal Artery Occlusion

Published on: July 19, 2011

Area of Science:

  • Nephrology
  • Critical Care Medicine
  • Pharmacology

Background:

  • Continuous renal replacement therapy (CRRT) is vital for critically ill patients with acute kidney injury (AKI), especially those with hemodynamic instability.
  • Effective CRRT delivery necessitates anticoagulation, posing challenges due to heightened bleeding and clotting risks in critically ill patients with sepsis and inflammation.
  • Inadequate anticoagulation compromises CRRT filter survival and therapeutic efficacy.

Purpose of the Study:

  • To review the role and challenges of anticoagulation in CRRT.
  • To explore various anticoagulation strategies beyond conventional heparin.
  • To highlight the growing acceptance of citrate anticoagulation in CRRT.

Main Methods:

  • Review of current literature on CRRT anticoagulation.
  • Comparison of different anticoagulation agents and regional techniques.
  • Analysis of advantages and disadvantages of each method.

Main Results:

  • Heparin is the most common CRRT anticoagulant but carries risks like hemorrhage, resistance, and heparin-induced thrombocytopenia (HIT).
  • Alternative anticoagulants include regional heparin/protamine, low molecular weight heparins, heparinoids, thrombin antagonists, regional citrate, and prostacyclin.
  • Citrate anticoagulation is increasingly favored due to simplified and safer protocols.

Conclusions:

  • Anticoagulation selection for CRRT must be individualized based on patient characteristics and institutional expertise.
  • Alternative anticoagulation methods offer distinct benefits and drawbacks compared to heparin.
  • Regional citrate anticoagulation represents a promising and increasingly adopted strategy for CRRT.