Related Experiment Video
Updated: Jun 23, 2026

Catheter-based Endovascular Angioplasty for Fibrosing Mediastinitis-associated Pulmonary Vein Stenosis
Published on: August 26, 2025
Successful treatment of phlegmasia cerulea dolens with combination surgical and catheter-assisted thrombectomy
Barbu Gociman1, Mario Castillo-Sang, Mohmmed Margni
1Department of Surgery, The University of Toledo Health Science Center, Toledo, OH 43614, USA. bgociman@utoledo.edu
Insights
Phlegmasia cerulea dolens, a rare condition from venous occlusion, requires prompt treatment to prevent limb loss. This case highlights successful treatment using catheter-assisted thrombectomy for extensive venous thrombosis.
Area of Science:
- Vascular Surgery
- Interventional Radiology
- Emergency Medicine
Background:
- Phlegmasia cerulea dolens (PCD) is a rare, severe condition caused by extensive venous thrombosis leading to arterial compromise.
- Prompt diagnosis and treatment are critical to prevent limb ischemia, gangrene, and mortality.
- Standard treatments include thrombolysis or surgical thrombectomy, especially when anticoagulation is contraindicated.
Observation:
- A 47-year-old male developed PCD after severe trauma and placement of an inferior vena cava filter.
- Initial attempts at balloon thrombectomy of the iliac veins and inferior vena cava were unsuccessful.
- The patient presented with caval thrombosis and progression to phlegmasia cerulea dolens.
Findings:
- Successful treatment was achieved with a combination of surgical thrombectomy of lower extremity veins and catheter-assisted thrombectomy of the iliac veins and inferior vena cava.
- Catheter-assisted thrombectomy avoided the need for laparotomy and direct caval thrombus evacuation.
- The patient experienced full symptom resolution with no residual venous clot on follow-up ultrasound.
Implications:
- Catheter-assisted thrombectomy offers a less invasive and effective alternative for treating PCD with impending gangrene.
- This approach can be crucial in complex cases where standard methods fail or are contraindicated.
- Timely and effective intervention can significantly improve patient outcomes, avoiding amputation and reducing mortality.
Abstract:
Phlegmasia cerulea dolens is a rare condition caused by complete venous occlusion that leads to impaired arterial flow. Prompt diagnosis and treatment initiation are paramount in preventing progression to gangrene, the need for amputation, and possibly the death of the patient. Thrombolysis or surgical thrombectomy, for advanced disease and cases in which anticoagulation is contraindicated, represent the current standard treatment. Here we report the case of a 47-year-old male who sustained severe trauma during a car accident. After having a prophylactic retrievable inferior vena cava filter placed, he developed caval thrombosis with progression to phlegmasia cerulea dolens. He was successfully treated with a combination of surgical thrombectomy of the lower extremity veins and catheter-assisted thrombectomy of the iliac veins and inferior vena cava, in the setting in which an initial attempt at balloon thrombectomy of the iliac veins and inferior vena cava failed. He was discharged from the hospital in stable condition and on follow-up visits had full resolution of symptoms. Ultrasound evaluation showed no residual venous clot. The presented case illustrates how the use of catheter-assisted thrombectomy alleviated the need for a laparotomy and direct caval evacuation of the thrombus and provided a timely and effective treatment of phlegmasia cerulea dolens with impending gangrene.
Related Concept Videos
Peripheral Artery Disease III: Interprofessional Care
Venous Thrombosis III: Interprofessional Care
Pulmonary Embolism II: Diagnostic Studies and Interprofessional Care
Varicose Veins II: Diagnostic Studies and Interprofessional Care
Peripheral Artery Disease V: Postoperative Nursing Management
Pulmonary Embolism III: Nursing Management