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Updated: Jun 23, 2026

Comprehensive Endovascular and Open Surgical Management of Cerebral Arteriovenous Malformations
Published on: October 20, 2017
Long-term sequelae after cerebral venous thrombosis in functionally independent patients
Karen Koopman1, Maarten Uyttenboogaart, Patrick C Vroomen
1Department of Neurology, University Medical Center Groningen, University of Groningen, the Netherlands. k.koopman@neuro.umcg.nl
Background:
The majority of survivors of cerebral venous thrombosis (CVT) regain functional independence, but it is unclear whether these patients experience long-term sequelae. The aim of this case-control study was to assess: (1) frequency of headache, fatigue, depression, and concentration impairment; and (2) impact of these sequelae on daily life and employment in patients with CVT who are functionally independent.
Methods:
We included 44 patients with CVT older than 15 years diagnosed between January 1997 and July 2006 who were functionally independent (modified Rankin scale score
Results:
Median follow-up was 63 months (range 12-124). In all, 33 patients (75%) reported concentration impairment, 19 (43%) had headache, 13 (30%) were depressive, and 13 (30%) experienced fatigue. All sequelae were more reported by patients than control subjects. The sequelae were correlated with each other, and with a higher psychosocial impact. Working was impossible for 8 (21%) and difficult for 13 (34%) of previously employed patients.
Conclusion:
In this case-control study, patients with CVT classified as having a good (independent) outcome often experience long-term symptoms that have a negative impact on their psychosocial and employment status.
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