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Updated: Jun 23, 2026

Knee Arthrocentesis in Adults
Published on: February 25, 2022
Proinflammatory cytokines in temporomandibular joint synovial fluid before and after arthrocentesis
Huseyin Gulen1, Hanife Ataoglu, Seyfullah Haliloglu
1Selcuk University, Faculty of Dentistry, Department of Oral and Maxillofacial Surgery, Konya, Turkey.
Objective:
The aim of this study was to evaluate the levels of interleukin (IL)-1beta, IL-6, IL-8, IL-11, and tumor necrosis factor (TNF)-alpha in temporomandibular joint (TMJ) synovial fluid of the patients with internal derangement before and 2 weeks after arthrocentesis.
Study Design:
Forty TMJs of 35 patients (29 females and 6 males, mean age 22.9 years) were included to the study. TMJs were divided into 2 groups: disc displacement with reduction (Group 1, n = 24) and disc displacement without reduction (Group 2, n = 16). Synovial fluid samples were obtained before and 2 weeks after arthrocentesis. IL-1beta, IL-6, IL-8, IL-11, and TNF-alpha concentrations were measured by using specific kits.
Results:
Two weeks after the arthrocentesis procedures, all cytokines were found to be significantly decreased (P < .05) both in Group 1 and Group 2. The difference between 2 groups was insignificant (P > .05).
Conclusion:
Arthrocentesis is an effective technique for eliminating the studied cytokines from the TMJ synovial fluid.
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