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Updated: Jun 23, 2026
07:31
A Syngeneic Orthotopic Osteosarcoma Sprague Dawley Rat Model with Amputation to Control Metastasis Rate
Published on: May 3, 2021
Synchronous osteosarcoma of mandible.
1Oral Medicine and Radiology, Bharati Vidyapeeth University Dental College and Hospital, Pune, India. dr.behere@gmail.com
Summary
This study reports a rare case of synchronous osteosarcoma, a type of bone cancer, affecting a teenage girl. The rare cancer involved the jawbone (mandible) along with other bones and potentially the lungs.
Area of Science:
- Oncology
- Orthopedics
- Radiology
Background:
- Osteosarcoma is the most common primary malignant bone tumor.
- Jaw osteosarcomas represent only 5% of all osteosarcoma cases.
- Synchronous osteosarcomas, occurring simultaneously, are rare, with an incidence of 1% to 3%.
Observation:
- A 16-year-old female presented with synchronous osteosarcoma.
- One lesion was located in the mandible (lower jaw).
- Additional lesions were found in the left femur, sixth thoracic vertebra, and suspected in the lungs.
Findings:
- The case highlights an extremely rare combination of synchronous osteosarcoma involving the mandible.
- Detailed imaging and histopathological features of the multiple osteosarcoma lesions are presented.
- The findings underscore the aggressive nature and potential for widespread metastasis of osteosarcoma.
Implications:
- This case contributes to the understanding of rare osteosarcoma presentations.
- It emphasizes the importance of comprehensive imaging in diagnosing synchronous bone malignancies.
- Further research into the pathogenesis and treatment of synchronous osteosarcoma, particularly with jaw involvement, is warranted.
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