Mesopic contrast sensitivity and ocular higher-order aberrations in eyes with conventional spherical intraocular...

To investigate relationship between mesopic contrast sensitivity (CS) function and ocular higher-order aberrations in eyes implanted with conventional spherical intraocular lenses (IOL).

Prospective, nonrandomized case series.

Sixty-eight eyes of 48 patients who attained best spectacle-corrected visual acuity (BSCVA) of 20/20 or better after phacoemulsification and spherical IOL implantation were included in the study. At 2 months postoperatively, mesopic CS was measured with the Mesotest II (Oculus; Wetsler, Germany), and ocular higher-order aberrations for a 4-mm pupil were measured with the Hartmann-Shack aberrometer. CS and letter CS under photopic conditions were recorded with the CSV-1000 charts (Vector Vision Co, Greenville, Ohio, USA).

There was significant correlation between mesopic CS and ocular fourth-order root mean square (RMS) of wavefront aberration (Spearman r(s) = -0.293; P = .017), but no correlation was found between mesopic CS and ocular third-order RMS (r(s) = 0.196; P = .189). Ocular third- and fourth-order RMS did not correlate with other parameters, including BSCVA, and CS and letter CS under photopic conditions.

Mesopic CS is significantly associated with ocular fourth-order RMS of wavefront aberrations in eyes implanted with conventional spherical IOLs.