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Related Concept Videos

Dose Size and Dosing Frequency: Determination Methods01:21

Dose Size and Dosing Frequency: Determination Methods

Determining the optimal dose size and dosing frequency in pharmacotherapy is crucial for achieving therapeutic effectiveness while minimizing adverse effects. This article explores the methodologies employed in determining these parameters, focusing on their significance and interplay to tailor dosing regimens.Dose Size: Dose size refers to the amount of a drug administered in a single dose. It is determined based on the drug's pharmacodynamics and pharmacokinetics properties and...

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Related Experiment Video

Updated: Jun 23, 2026

Characterization of Recombination Effects in a Liquid Ionization Chamber Used for the Dosimetry of a Radiosurgical Accelerator
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Published on: May 9, 2014

[Quality control in pulsed dose rate brachytherapy].

Y Métayer1, P Meyer, C Brunaud

  • 1Unité de radiophysique, centre Alexis-Vautrin, avenue de Bourgogne, 54511 Vandoeuvre-lès-Nancy cedex, France. y.metayer@nancy.fnclcc.fr

Cancer Radiotherapie : Journal De La Societe Francaise De Radiotherapie Oncologique
|May 12, 2009
PubMed
Summary

This study compared pulsed dose rate (PDR) brachytherapy to traditional treatments for cervix carcinoma. PDR brachytherapy demonstrated comparable local control and complication rates with optimized costs.

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Proton Therapy Delivery and Its Clinical Application in Select Solid Tumor Malignancies
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Last Updated: Jun 23, 2026

Characterization of Recombination Effects in a Liquid Ionization Chamber Used for the Dosimetry of a Radiosurgical Accelerator
07:31

Characterization of Recombination Effects in a Liquid Ionization Chamber Used for the Dosimetry of a Radiosurgical Accelerator

Published on: May 9, 2014

Proton Therapy Delivery and Its Clinical Application in Select Solid Tumor Malignancies
08:34

Proton Therapy Delivery and Its Clinical Application in Select Solid Tumor Malignancies

Published on: February 6, 2019

Area of Science:

  • Oncology
  • Radiotherapy
  • Medical Physics

Context:

  • Cervix carcinoma treatment landscape.
  • Evaluation of brachytherapy techniques in a multicenter setting.
  • French Ministry of Health supported Stic-PDR program.

Purpose:

  • To assess the cost-effectiveness of pulsed dose rate (PDR) brachytherapy with dose optimization versus traditional brachytherapy.
  • To evaluate and compare complication rates and local control between PDR and conventional brachytherapy for cervix cancer.
  • To establish and detail a quality control program for brachytherapy procedures.

Summary:

  • A prospective, multicenter study involving 850 patients with cervix carcinoma compared 2D classic and 3D innovative brachytherapy (425 patients each arm) over two years (2005-2006).
  • A joint quality control program was implemented by physicists, covering treatment planning software, source replacement, projectors, and technical parameters.
  • The study focused on cost assessment, complication evaluation, and local control rates for PDR brachytherapy against traditional methods.

Impact:

  • Provides crucial data on the economic and clinical outcomes of PDR brachytherapy in cervix cancer management.
  • Highlights the importance of standardized quality control in advanced radiotherapy techniques.
  • Informs clinical decision-making regarding the adoption of PDR brachytherapy for improved patient care and resource allocation.