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Updated: Jun 23, 2026

Large-Scale Production of Cardiomyocytes from Human Pluripotent Stem Cells Using a Highly Reproducible Small Molecule-Based Differentiation Protocol
Published on: July 25, 2016
Using small molecules to great effect in stem cell differentiation
1Cell and Developmental Biology Program, Fox Chase Cancer Center, Philadelphia, PA 19111, USA. zaret@fccc.edu
Abstract:
Several recent reports, including two Cell Stem Cell papers (Zhu et al., 2009 [this issue]; Borowiak et al., 2009), screened small molecule libraries for compounds that promote embryonic stem cell differentiation. Their combined success helps bypass challenges associated with using natural protein factors and has revealed insights into controlling stem cell differentiation.
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