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Updated: Jun 23, 2026

Homing of Hematopoietic Cells to the Bone Marrow
10:40

Homing of Hematopoietic Cells to the Bone Marrow

Published on: March 18, 2009

Galpha(s) uncouples hematopoietic stem cell homing and mobilization

Simón Méndez-Ferrer1, Paul S Frenette

  • 1Department of Medicine, Mount Sinai School of Medicine, New York, NY 10029, USA.

Cell Stem Cell
|May 12, 2009
PubMed

Defects of hematopoietic stem cell adhesion or migration generally lead to reduced homing to, and enhanced mobilization from, the bone marrow. In a recent publication in Nature, Adams et al. (2009) demonstrate that the guanine-nucleotide-binding stimulatory alpha subunit (Galpha(s)) can, unexpectedly, promote both phenomena.

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