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Updated: Jun 23, 2026

A Murine Model of Dengue Virus-induced Acute Viral Encephalitis-like Disease

A Murine Model of Dengue Virus-induced Acute Viral Encephalitis-like Disease

Published on: April 28, 2019

Oxidative damage in dengue fever.

Raymond C S Seet¹, Chung-Yung J Lee, Erle C H Lim

¹Department of Medicine, Yong Loo Lin School of Medicine, National University Hospital, Singapore 119074. raymond_seet@nus.edu.sg

Free Radical Biology & Medicine

|May 12, 2009

Summary

Oxidative stress markers, including hydroxyeicosatetraenoic acid products (HETEs) and cholesterol oxidation products (COPs), are elevated during the febrile stage of dengue infection. These changes correlate with clinical parameters, indicating oxidative damage

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Screening Assay for Oxidative Stress in a Feline Astrocyte Cell Line, G355-5

Screening Assay for Oxidative Stress in a Feline Astrocyte Cell Line, G355-5

Published on: July 13, 2011

Area of Science:

Biochemistry
Pathophysiology
Clinical Medicine

Background:

Oxidative stress is implicated in the pathogenesis of dengue infection.
Accurate markers are needed to quantify oxidative damage in dengue patients.

Purpose of the Study:

To assess the extent of oxidative damage in dengue patients using specific biomarkers.
To correlate oxidative damage markers with clinical and inflammatory parameters during different infection stages.

Main Methods:

Measured hydroxyeicosatetraenoic acid products (HETEs), F(2)-isoprostanes (F(2)-IsoPs), and cholesterol oxidation products (COPs) in 28 dengue patients and 28 controls.
Analyzed marker levels during febrile, defervescent, and convalescent stages.
Correlated marker changes with clinical parameters and inflammatory markers.

Main Results:

Total HETEs, F(2)-IsoPs/arachidonate, and COPs/cholesterol were higher during the febrile stage compared to convalescent.
Elevated HETEs correlated with higher systolic blood pressure; 7beta-hydroxycholesterol inversely correlated with blood pressure.
Urinary F(2)-IsoP levels and percentage of cholesterol as COPs were higher during fever.

Conclusions:

Oxidative damage markers are significantly altered during dengue infection stages.
Specific oxidative stress products show distinct patterns and correlations with clinical severity.
Findings highlight the role of oxidative stress in dengue pathogenesis.