Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Diabetic Nephropathy01:28

Diabetic Nephropathy

Definition Diabetic nephropathy is a chronic kidney complication that results from prolonged hyperglycemia.Prevalence It is the most common cause of chronic kidney disease (CKD) and end-stage renal disease (ESRD) worldwide, affecting up to half of individuals with diabetes.Pathophysiology • Sustained hyperglycemia triggers multiple hemodynamic and metabolic changes in the kidney. • Early in the disease, increased renal blood flow and glomerular hyperfiltration occur due to afferent arteriolar...
Heart Failure II: Pathophysiology01:29

Heart Failure II: Pathophysiology

Systolic Heart Failure and Compensatory MechanismsSystolic heart failure (also termed HFrEF, Heart Failure with Reduced Ejection Fraction) is the most prevalent type of heart filure. It results in a decreased volume of blood being pumped from the ventricle. The aortic arch and carotid sinuses have baroreceptors that detect reduced blood pressure, triggering the sympathetic nervous system (SNS) to release epinephrine and norepinephrine. Initially, this response aims to boost heart rate and...
Diabetic Neuropathy01:22

Diabetic Neuropathy

DefinitionDiabetic neuropathy is nerve damage caused by long-standing diabetes mellitus. It results directly from prolonged high blood sugar levels.PathophysiologyThe pathophysiology of diabetic neuropathy involves both metabolic and vascular disturbances triggered by chronic hyperglycemia.Metabolic injury: Elevated glucose levels activate the polyol pathway within nerve cells, leading to the accumulation of sorbitol and fructose. This increases oxidative stress, disrupts normal nerve...
Diabetic Retinopathy01:27

Diabetic Retinopathy

DefinitionDiabetic retinopathy is a microvascular complication of diabetes affecting the retinal blood vessels.Risk FactorsDiabetic retinopathy is present in almost all individuals with type 1 diabetes and more than 60% of those with type 2 diabetes after two decades of disease.The risk increases with poor glycemic control, hypertension, dyslipidemia, smoking, pregnancy, and puberty.Although cataracts and glaucoma are also more frequent in people with diabetes, retinopathy remains the leading...
Cardiomyopathy II: Dilated Cardiomyopathy01:30

Cardiomyopathy II: Dilated Cardiomyopathy

Dilated cardiomyopathy, or DCM, is a progressive myocardial disorder characterized by ventricular chamber dilation and contractile dysfunction.EtiologyVarious factors can cause DCM, including hypertension and heavy alcohol intake, which contribute to the weakening and enlargement of the heart muscle. Viral infections, such as Coxsackievirus B, adenoviruses, and influenza, can lead to DCM by causing inflammation and damage to heart tissue. Certain chemotherapeutic agents, including daunorubicin,...
Type II Diabetes II: Pathophysiology01:24

Type II Diabetes II: Pathophysiology

PathophysiologyType 2 diabetes mellitus (T2DM ) is a chronic metabolic disorder characterized by insulin resistance and progressive pancreatic β-cell dysfunction, leading to impaired glucose homeostasis. It results from interactions among genetic predisposition, environmental factors, and metabolic stressors, such as overnutrition and a sedentary lifestyle.Insulin Resistance and Glucose DysregulationEarly T2DM involves insulin resistance in skeletal muscle, adipose tissue, and the liver.

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Concomitant Moderate Aortic Stenosis with Moderate Mitral Regurgitation in Patients with Normal Ejection Fraction: Types, Natural History and Outcomes.

Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography·2026
Same author

Diagnostic Performance of the Mayo ATTR-CM Score in Diverse Populations: Comparison With the AMY Score.

JACC. Advances·2026
Same author

Prognostic Value of Tricuspid Regurgitation in Pulmonary Hypertension and Among the Different WHO Groups.

JACC. Cardiovascular imaging·2026
Same author

Relation of Doppler-Derived Regurgitant Fraction to Regurgitant Volume in Chronic Aortic Regurgitation and Implications for Prognosis.

Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography·2026
Same author

Prevalence and Burden of Cardiac Amyloidosis in a Population-Based Autopsy Cohort.

Circulation·2026
Same author

Time-Critical Cardiovascular Risk After COVID-19: A Population-Based Analysis Across Variant Eras.

Mayo Clinic proceedings. Innovations, quality & outcomes·2026

Related Experiment Video

Updated: Jun 23, 2026

Quantification of Global Diastolic Function by Kinematic Modeling-based Analysis of Transmitral Flow via the Parametrized Diastolic Filling Formalism
11:04

Quantification of Global Diastolic Function by Kinematic Modeling-based Analysis of Transmitral Flow via the Parametrized Diastolic Filling Formalism

Published on: September 1, 2014

Changes in diastolic dysfunction in diabetes mellitus over time.

Aaron M From1, Christopher G Scott, Horng H Chen

  • 1Division of Cardiovascular Diseases, Mayo Clinic and Foundation, Rochester, Minnesota, USA.

The American Journal of Cardiology
|May 12, 2009
PubMed
Summary

Diabetes duration significantly worsens left ventricular diastolic dysfunction. Longer diabetes duration (≥4 years) is linked to increased dysfunction and predicts all-cause mortality in diabetic patients, independent of other conditions.

More Related Videos

Noninvasive Determination of Vortex Formation Time Using Transesophageal Echocardiography During Cardiac Surgery
04:48

Noninvasive Determination of Vortex Formation Time Using Transesophageal Echocardiography During Cardiac Surgery

Published on: November 28, 2018

Related Experiment Videos

Last Updated: Jun 23, 2026

Quantification of Global Diastolic Function by Kinematic Modeling-based Analysis of Transmitral Flow via the Parametrized Diastolic Filling Formalism
11:04

Quantification of Global Diastolic Function by Kinematic Modeling-based Analysis of Transmitral Flow via the Parametrized Diastolic Filling Formalism

Published on: September 1, 2014

Noninvasive Determination of Vortex Formation Time Using Transesophageal Echocardiography During Cardiac Surgery
04:48

Noninvasive Determination of Vortex Formation Time Using Transesophageal Echocardiography During Cardiac Surgery

Published on: November 28, 2018

Area of Science:

  • Cardiology
  • Endocrinology
  • Medical Diagnostics

Background:

  • Preclinical left ventricular (LV) diastolic dysfunction is observed in diabetes mellitus (DM) patients, irrespective of coronary disease or hypertension.
  • The impact of DM duration on LV diastolic dysfunction requires further quantification.

Purpose of the Study:

  • To determine if LV diastolic dysfunction, assessed by tissue Doppler indexes, worsens with increasing DM duration.
  • To quantify the severity of LV diastolic dysfunction as a function of DM duration.

Main Methods:

  • Retrospective analysis of 486 Olmsted County residents with incident DM and subsequent tissue Doppler echocardiography (1996-2007).
  • Linear regression used to assess the association between E/e' ratio and DM duration.
  • Logistic regression and proportional hazard modeling adjusted for clinical covariates to determine associations with dysfunction and mortality.

Main Results:

  • Each year of DM duration was associated with a 0.23 increase in the E/e' ratio (p=0.007).
  • DM duration of ≥4 years was independently associated with LV diastolic dysfunction (E/e' >15; OR 1.91, p=0.007).
  • Elevated E/e' ratio predicted all-cause mortality (HR 1.11, p=0.005) independent of other risk factors.

Conclusions:

  • Diabetes mellitus duration of 4 years or more correlates with significant LV diastolic dysfunction.
  • LV diastolic dysfunction in DM patients is a predictor of all-cause mortality, independent of hypertension and coronary disease.